Hypersensitivity reactions following vein closure therapy with venasealTM (n-butyl- 2-cyanoacrylate)

VenaSeal TM is composed of a cyanoacrylate adhesive compound often utilized for chronic venous stasis treatment. Rare case reports of hypersensitivity reactions to this compound exist. We present the first case of dermatographism and angioedema after utilization of VenaSeal TM successfully treated via high dose antihistamines. We also present a case of type IV hypersensitivity to VenaSeal TM , a cyanoacrylate, occurring in a patient with known meth(acrylate) allergy indicating a possible cross reactivity between these acrylate groups.