焦虑
厌食症
自闭症
色氨酸
褪黑素
神经性厌食
血清素
饮食失调
医学
保健品
疾病
睡眠(系统调用)
萧条(经济学)
精神科
生物信息学
生物
内分泌学
氨基酸
内科学
生物化学
受体
经济
宏观经济学
操作系统
计算机科学
作者
Joanna Kałużna–Czaplińska,Paulina Gątarek,Salvatore Chirumbolo,Max Stanley Chartrand,Geir Bjørklund
标识
DOI:10.1080/10408398.2017.1357534
摘要
Tryptophan (Trp) is an amino acid and an essential component of the human diet. It plays a crucial role in many metabolic functions. Clinicians can use Trp levels in the course of diagnosing various metabolic disorders and the symptoms associated with those diseases. Furthermore, supplementation with this amino acid is considered in the treatment of depression and sleep disorders, mainly due to the Trp relationship with the synthesis of serotonin (5-HT) and melatonin. It is also used in helping to resolve cognitive disorders, anxiety, or neurodegenerative diseases. Reduced secretion of serotonin is associated with autism spectrum disorder, obesity, anorexia and bulimia nervosa, and other diseases presenting peripherals symptoms. The literature strongly suggests that Trp has a significant role in the correct functionality of the brain-gut axis and immunology. This information leads to the consideration of Trp as an essential dietary component due to its role in the serotonin pathway. A reduced availability of Trp in diet and nutraceutical supplementation should be considered with greater concern than one might expect. This paper constitutes a review of the more salient aspects gleaned from the current knowledge base about the role of Trp in diseases, associated nutritional disorders, and food science, in general.
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