神经认知
认知
乳腺癌
召回
心理学
荟萃分析
言语记忆
执行职能
工作记忆
多级模型
听力学
睡眠剥夺对认知功能的影响
临床心理学
癌症
肿瘤科
医学
内科学
精神科
认知心理学
机器学习
计算机科学
作者
Lori J. Bernstein,Graham A. McCreath,Zahra Komeylian,Jill B. Rich
标识
DOI:10.1016/j.neubiorev.2017.10.028
摘要
Women with breast cancer can experience persisting cognitive deficits post treatment. We conducted a multilevel meta-analysis of cognitive function in survivors treated with chemotherapy (Ch+) to estimate the magnitude of cognitive impairment relative to healthy (HC) and chemo-negative (Ch−) controls. Seventy-two studies published up to October 2016 involving 2939 Ch+ yielded 1594 effect sizes. Ch+ demonstrated overall cognitive impairment in comparison with HC but not with Ch−. Relative to HC, Ch+ showed impairment in attention/concentration, processing speed, language, immediate recall, delayed recall, and executive function. Deficits in memory recall and executive function remained significant after adjusting for prechemotherapy group differences. Ch+ performed worse than Ch− in attention/concentration and executive function, and the groups performed equivalently after accounting for prechemotherapy neurocognitive differences. These results demonstrate that cognitive deficits in Ch+ depend in large part on the comparison group, the cognitive domains examined, and whether prechemotherapy baseline neurocognition is measured. Cancer and/or other treatment-related factors contribute to subtle memory recall and executive function impairments in breast cancer survivors.
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