自愈水凝胶
伤口愈合
壳聚糖
乙烯醇
材料科学
伤口敷料
乙二醇
胰岛素
活力测定
药理学
生物医学工程
化学
细胞
高分子化学
生物化学
医学
外科
有机化学
聚合物
内科学
复合材料
作者
Lingling Zhao,Lijing Niu,Hongze Liang,Hui Tan,Chaozong Liu,Feiyan Zhu
标识
DOI:10.1021/acsami.7b09395
摘要
pH and glucose dual-responsive injectable hydrogels were prepared through the cross-linking of Schiff's base and phenylboronate ester using phenylboronic-modified chitosan, poly(vinyl alcohol) and benzaldehyde-capped poly(ethylene glycol). Protein drugs and live cells could be incorporated into the hydrogels during the in situ cross-linking, displaying sustained and pH/glucose-triggered drug release from the hydrogels and cell viability and proliferation in the three-dimensional hydrogel matrix as well. Hence, the hydrogels with insulin and fibroblasts were considered as bioactive dressings for diabetic wound healing. A streptozotocin-induced diabetic rat model was used to evaluate the efficacy of hydrogel dressings in wound repair. The results revealed that the incorporation of insulin and L929 in the hydrogels could promote neovascularization and collagen deposition and enhance the wound-healing process of diabetic wounds. Thus, the drug- and cell-loaded hydrogels have promising potential in wound healing as a medicated system for various therapeutic proteins and live cells.
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