Wnt信号通路
大肠腺瘤性息肉病
生物
癌变
细胞生物学
信号转导
再生(生物学)
平衡
果蝇属(亚属)
抑制器
干细胞
遗传学
结直肠癌
癌症
基因
作者
Ai Tian,Hassina Benchabane,Yashi Ahmed
摘要
In mammals, the Wnt/β-catenin signal transduction pathway regulates intestinal stem cell maintenance and proliferation, whereas Wnt pathway hyperactivation, resulting primarily from the inactivation of the tumor suppressor Adenomatous polyposis coli (APC), triggers the development of the vast majority of colorectal cancers. The Drosophila adult gut has recently emerged as a powerful model to elucidate the mechanisms by which Wingless/Wnt signaling regulates intestinal development, homeostasis, regeneration, and tumorigenesis. Herein, we review recent insights on the roles of Wnt signaling in Drosophila intestinal physiology and pathology.
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