When to Suspect Systemic Mastocytosis?

皮肤肥大细胞增多 医学 全身性肥大细胞增多症 色素性荨麻疹 皮肤病科 细胞减少 肥大细胞瘤 皮肤活检 活检 血管性水肿 内科学 疾病 骨髓 癌症研究 肿瘤细胞
作者
Sibel Kaplan,Barış Kuşkonmaz,özge Ulusoy Soyer,Selin Aytaç,Fatma Gümrük
出处
期刊:Blood [American Society of Hematology]
卷期号:132 (Supplement 1): 5826-5826
标识
DOI:10.1182/blood-2018-99-119809
摘要

Abstract Background : Mastocytosis is a rare disease in children and it usually resolves by adolesence.However; it causes anxiety in parents and should be taken into consideration in patients with cutaneous eritematous lesions. Aim: To find out the systemic mastocytosis patients who apply to pediatric hematology , pediatric allergy and dermatology policlinics. Material and Methods: The files of 24 patients diagnosed with mastocytosis between January 2018 and August 2018 in our clinic were retrospectively analyzed. Results: All patients had cutaneous mastocytosis, 14 patients had urticaria pigmentosa and 9 patients had solitary mastocytoma and one patient had diffuse cutaneous mastocytosis. The male-female ratio was: 2/1. The median age for onset of disease was 7,2 (0-48 months )months. The patients had different types of skin findings such as macules (n=16), plaques(n=6), papules(n=4) and bullae(n=3). None of the patients had anaphylaxis but two patients had angioedema. The diagnosis was confirmed with skin biopsy in 8 patients. The other were diagnosed due to typical history and physical examination. None of the patients had cytopenia, hepatosplenomegaly.Only one patient triptase level >20 ug/l. The bone marrow aspiration and biopsy was done to 3 patients and all were normal.The patients were treated with H2 antihistaminics, local moisturizing creams and topical corticosteroid drugs in case of undesirable pruritus. Conclusions: Most cases of childhood mastocytosis are observed in the form of cutaneous mastocytosis and ıt usually resolves by adolescence. If the patients have cytopenia, hepatosplenomagaly or triptase level >20 ug/l the bone marrow aspiration and biopsy is recommended. Disclosures No relevant conflicts of interest to declare.

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
耿昊发布了新的文献求助10
1秒前
wwwwww发布了新的文献求助10
1秒前
1秒前
2秒前
田様应助LIYUAN采纳,获得10
2秒前
Akim应助不住采纳,获得10
2秒前
科研通AI6.2应助空白采纳,获得10
5秒前
5秒前
5秒前
5秒前
5秒前
5秒前
6666发布了新的文献求助20
6秒前
7秒前
冷酷的牛排完成签到,获得积分10
8秒前
有猫发布了新的文献求助10
8秒前
燚y完成签到,获得积分10
9秒前
qu发布了新的文献求助10
10秒前
顾矜应助朱琼慧采纳,获得10
10秒前
lulu666666完成签到,获得积分10
10秒前
11秒前
河神发布了新的文献求助10
12秒前
Luo完成签到,获得积分10
12秒前
深情安青应助耿昊采纳,获得10
12秒前
爱笑的乌皮神兽关注了科研通微信公众号
13秒前
13秒前
量子星尘发布了新的文献求助10
13秒前
852应助七七采纳,获得10
13秒前
15秒前
范范发布了新的文献求助10
15秒前
15秒前
15秒前
16秒前
QXS发布了新的文献求助80
16秒前
gyh应助韩世星采纳,获得30
16秒前
17秒前
17秒前
17秒前
所所应助YYY采纳,获得10
17秒前
高分求助中
(应助此贴封号)【重要!!请各用户(尤其是新用户)详细阅读】【科研通的精品贴汇总】 10000
Aerospace Standards Index - 2026 ASIN2026 3000
Polymorphism and polytypism in crystals 1000
Signals, Systems, and Signal Processing 610
Discrete-Time Signals and Systems 610
Research Methods for Business: A Skill Building Approach, 9th Edition 500
Social Work and Social Welfare: An Invitation(7th Edition) 410
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 纳米技术 有机化学 物理 生物化学 化学工程 计算机科学 复合材料 内科学 催化作用 光电子学 物理化学 电极 冶金 遗传学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 6049350
求助须知:如何正确求助?哪些是违规求助? 7837489
关于积分的说明 16263041
捐赠科研通 5194787
什么是DOI,文献DOI怎么找? 2779623
邀请新用户注册赠送积分活动 1762833
关于科研通互助平台的介绍 1644831