P6549Inflammasome-induced endothelial microparticles impair cellular function in arterial smooth muscle cells

医学 平滑肌 功能(生物学) 细胞生物学 内科学 生物
作者
Philipp Pfeifer,Ansgar Ackerschott,S.K. Ebert,J Jehle,Eicke Latz,Bernardo S. Franklin,Georg Nickenig,Nikos Werner,Sebastian Zimmer,Felix Jansen
出处
期刊:European Heart Journal [Oxford University Press]
卷期号:39 (suppl_1) 被引量:1
标识
DOI:10.1093/eurheartj/ehy566.p6549
摘要

Introduction:Telomeres are tandem repeats of DNA sequences located at the chromosomal ends that function to stabilise the genetic structure.The relevance of telomeres has been shown for different human disorders including cardiovascular disease.Yet, the majority of these studies was performed in disease specific cohorts with small samples sizes.Purpose: The aim of this study was to evaluate the association of relative telomere length (RTL) with cardiovascular risk factors and cardiovascular disease in a large population based cohort.Methods: RTL was measured according to a previously validated real-time quantitative polymerase chain reaction technique in subjects of the Gutenberg Health Study (n=5000).An association study of RTL with cardiovascular risk factors smoking status, LDL, HDL, triglycerides, BMI, systolic and diastolic blood pressure as well as an association study of RTL with cardiovascular diseases heart failure with reduced ejection fraction (HF-REF), heart failure with preserved ejection fraction (HF-PEF), myocardial infarction (MI), family history of MI, coronary artery disease (CAD) and atrial fibrillation (AF) was performed.Results: A significant association was found between RTL and smoking status (effect -0.016, p=0.048), however, no association was found with lipid levels, blood pressure and BMI.For cardiovascular disease, a moderate association was found with heart failure with preserved ejection fraction (effect: -0.030, p=0.062).Interestingly, RTL also associated significantly with the surrogate biomarkers of heart failure NT-proBNP (effect: -0.007, p=0.009) as well as Troponin I (effect: -1.495, p=0.040).In contrast, no association of RTL was found with HF-REF, MI, family history of MI, CAD, AF. Conclusion:In a large population based study, RTL showed only moderate association to smoking and markers of heart failure, however for the majority of cardiovascular diseases no significant association was detected.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
可乐完成签到,获得积分10
2秒前
wdy111举报徐per爱豆求助涉嫌违规
2秒前
3秒前
4秒前
4秒前
漂亮白枫完成签到,获得积分10
5秒前
情怀应助why359采纳,获得10
5秒前
CodeCraft应助wsj采纳,获得10
5秒前
5秒前
领导范儿应助DoctorDiDi采纳,获得10
5秒前
LaTeXer应助勤恳白山采纳,获得80
5秒前
8秒前
小爪冰凉发布了新的文献求助30
8秒前
9秒前
漂亮白枫发布了新的文献求助10
9秒前
9秒前
10秒前
10秒前
优雅灵波发布了新的文献求助10
11秒前
kong完成签到,获得积分10
12秒前
12秒前
JJ发布了新的文献求助10
12秒前
幸福大白发布了新的文献求助10
13秒前
14秒前
14秒前
123完成签到,获得积分10
14秒前
Qing完成签到,获得积分10
15秒前
小二郎应助搞笑5次采纳,获得10
15秒前
ZONG发布了新的文献求助20
17秒前
yyyyyyy发布了新的文献求助10
18秒前
勤奋幻柏发布了新的文献求助10
18秒前
why359发布了新的文献求助10
19秒前
19秒前
20秒前
21秒前
hahah完成签到,获得积分10
23秒前
伶俐绿柏发布了新的文献求助10
25秒前
狸宝的小果子完成签到 ,获得积分10
25秒前
汉堡包应助wzc采纳,获得10
25秒前
深情安青应助刀锋采纳,获得10
26秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989450
求助须知:如何正确求助?哪些是违规求助? 3531621
关于积分的说明 11254315
捐赠科研通 3270207
什么是DOI,文献DOI怎么找? 1804928
邀请新用户注册赠送积分活动 882105
科研通“疑难数据库(出版商)”最低求助积分说明 809176