Associations of dietary choline intake with risk of incident dementia and with cognitive performance: the Kuopio Ischaemic Heart Disease Risk Factor Study

痴呆 医学 四分位数 风险因素 内科学 胆碱 人口 认知功能衰退 前瞻性队列研究 老年学 内分泌学 疾病 置信区间 环境卫生
作者
Maija PT Ylilauri,Sari Voutilainen,Eija Lönnroos,Heli EK Virtanen,Tomi‐Pekka Tuomainen,Jukka T. Salonen,Jyrki K. Virtanen
出处
期刊:The American Journal of Clinical Nutrition [Elsevier BV]
卷期号:110 (6): 1416-1423 被引量:70
标识
DOI:10.1093/ajcn/nqz148
摘要

Moderate egg intake has been associated with better cognitive performance in observational studies. This association may be due to the rich content of choline, especially phosphatidylcholine, in eggs because choline has been suggested to have a role in the prevention of cognitive decline. We investigated the associations of dietary choline intake with the risk of incident dementia and with cognitive performance in middle-aged and older men in the prospective, population-based Kuopio Ischaemic Heart Disease Risk Factor Study. A population-based sample of 2497 dementia-free men aged 42–60 y was examined in 1984–1989. A subset of 482 men completed 5 different cognitive performance tests 4 y later. Dementia and Alzheimer disease diagnoses were retrieved from Finnish health registers. Dietary intakes were assessed with the use of 4-d food records at baseline. Cox regression and ANCOVA were used for the analyses. All analyses were also stratified by the apolipoprotein E phenotype (APOE-ε4 compared with other phenotypes). These data were available for 1259 men. The mean ± SD total choline intake was 431 ± 88 mg/d, of which 188 ± 63 mg/d was phosphatidylcholine. During a 21.9-y follow-up, 337 men were diagnosed with dementia. Those in the highest compared with the lowest phosphatidylcholine intake quartile had 28% (95% CI: 1%, 48%; P-trend = 0.02 across quartiles) lower multivariable-adjusted risk of incident dementia. Total choline intake had no association with the risk of incident dementia. However, both total choline and phosphatidylcholine intakes were associated with better performance in cognitive tests assessing frontal and temporal lobe functioning. For example, higher intakes were associated with better performance in verbal fluency and memory functions. The APOE phenotype had little or no impact on the associations. Higher phosphatidylcholine intake was associated with lower risk of incident dementia and better cognitive performance in men in eastern Finland. This trial was registered at clinicaltrials.gov as NCT03221127.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
戴好头盔搞科研完成签到,获得积分10
刚刚
YZP完成签到,获得积分10
1秒前
1秒前
2秒前
2秒前
wjx发布了新的文献求助10
2秒前
xixi完成签到,获得积分20
3秒前
3秒前
3秒前
4秒前
stayreal发布了新的文献求助10
4秒前
4秒前
4秒前
LONG完成签到 ,获得积分10
4秒前
5秒前
5秒前
朱凌霄完成签到,获得积分10
6秒前
我不会科研完成签到,获得积分10
6秒前
QUA完成签到,获得积分10
6秒前
catalyst发布了新的文献求助10
6秒前
独特的雁桃完成签到,获得积分10
7秒前
xixi发布了新的文献求助30
7秒前
7秒前
TruongThe发布了新的文献求助30
8秒前
8秒前
9秒前
陌上花开发布了新的文献求助10
9秒前
周杰伦完成签到,获得积分10
9秒前
10秒前
hzl完成签到,获得积分10
10秒前
酷酷巧蟹发布了新的文献求助10
10秒前
10秒前
量子星尘发布了新的文献求助20
11秒前
Yelicious发布了新的文献求助10
11秒前
刘刘刘完成签到 ,获得积分10
12秒前
mayberichard发布了新的文献求助10
12秒前
axiang发布了新的文献求助10
12秒前
善学以致用应助71采纳,获得10
14秒前
yydragen应助樱悼柳雪采纳,获得30
14秒前
shinn发布了新的文献求助30
14秒前
高分求助中
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
Effective Learning and Mental Wellbeing 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3975165
求助须知:如何正确求助?哪些是违规求助? 3519595
关于积分的说明 11198781
捐赠科研通 3255912
什么是DOI,文献DOI怎么找? 1798001
邀请新用户注册赠送积分活动 877343
科研通“疑难数据库(出版商)”最低求助积分说明 806298