Gastric emptying of indigestible tablets in relation to composition and time of ingestion of meals studied by metal detector

胃排空 摄入 医学 胃肠病学 内科学 早晨 动物科学 生物
作者
Klaus Ewe,A. G. Press,Susanne Bollen,Ilse Schuhn
出处
期刊:Digestive Diseases and Sciences [Springer Science+Business Media]
卷期号:36 (2): 146-152 被引量:46
标识
DOI:10.1007/bf01300748
摘要

Enteric-coated tablets leave the stomach mainly during the interdigestive phase. Composition as well as time of ingestion of meals may influence their gastric emptying considerably. In 12 normal volunteers gastric emptying of a plastic tablet with a metal core was followed by a metal detector in relation to different compositions and various times of ingestion of meals. With an empty stomach and after ingestion of 250 ml water, the mean time for gastric emptying of the tablet was 38±11 min (mean±SEM) and 38±8 min. Two hundred fifty milliliters of milk (652 kJ) and a formula diet (1000 kJ) delayed gastric emptying time to 128±14 and 152±6 min, respectively (P<0.05). Breakfast (2200 kJ) further retarded gastric emptying compared with both liquids to 249±24 min (P<0.05). There was a close correlation between nutritive density and gastric emptying of the tablet (r=0.92;P<0.0001). Main meals also delayed gastric emptying of tablets when compared to empty stomach (P<0.05). A snack after breakfast further delayed gastric emptying from 201±10 to 278±19 min (P<0.05). The largest delay was observed following ingestion of breakfast, lunch, dinner, and additional snacks (509±220 min). We conclude that the delay of gastric emptying of enteric-coated tablets by food is related to its nutritive density and eating habits. The gastric emptying of an enteric coated tablet that is ingested early in the morning may be delayed until late at night when several meals and snacks are ingested during the day, leading to unwanted alterations in bioavailability and to possible adverse effects.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
刚刚
Giinjju发布了新的文献求助10
1秒前
1秒前
小蘑菇应助刻苦海露采纳,获得30
1秒前
迷路铸海发布了新的文献求助10
2秒前
4秒前
充电宝应助Han采纳,获得10
5秒前
帅帅发布了新的文献求助10
6秒前
星期八发布了新的文献求助10
6秒前
7秒前
顾矜应助LittleTT采纳,获得10
7秒前
善学以致用应助钙离子采纳,获得10
8秒前
量子星尘发布了新的文献求助10
9秒前
猪猪侠发布了新的文献求助10
9秒前
玛卡巴卡发布了新的文献求助10
10秒前
11秒前
11秒前
11秒前
Bryan应助Wenhao采纳,获得10
12秒前
帅帅完成签到,获得积分20
13秒前
向北完成签到,获得积分10
14秒前
14秒前
研友_qZ6V1Z完成签到,获得积分10
14秒前
猪猪侠完成签到,获得积分10
14秒前
15秒前
16秒前
czz发布了新的文献求助10
16秒前
Han发布了新的文献求助10
16秒前
16秒前
桐桐应助Rosie采纳,获得10
17秒前
18秒前
沉淀体育生完成签到,获得积分10
19秒前
song发布了新的文献求助10
19秒前
20秒前
奋斗的菀发布了新的文献求助10
21秒前
1101592875完成签到,获得积分10
21秒前
毛哥发布了新的文献求助10
22秒前
fuje发布了新的文献求助10
23秒前
权归尘发布了新的文献求助10
24秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Effective Learning and Mental Wellbeing 400
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3975871
求助须知:如何正确求助?哪些是违规求助? 3520207
关于积分的说明 11201502
捐赠科研通 3256611
什么是DOI,文献DOI怎么找? 1798403
邀请新用户注册赠送积分活动 877552
科研通“疑难数据库(出版商)”最低求助积分说明 806430