氧化应激
丙二醛
肾
超氧化物歧化酶
谷胱甘肽
内科学
内分泌学
抗氧化剂
组织病理学检查
化学
药理学
医学
病理
生物化学
酶
作者
Jaya Raj,Jaya M. Raj,A C Rajvanshi,T.D. Dogra,Anupuma Raina
出处
期刊:PubMed
日期:2014-08-01
卷期号:52 (8): 814-9
被引量:7
摘要
Acute dose of organophosphorus pesticide Triazophos (O,O-diethyl O-1-phenyl-1H-1,2,4-triazol-3-yl phosphorothioate; Tz) administered orally affects oxidative stress parameters and the histo-architecture of liver, kidney and brain tissues. The results indicate a dose dependent induction of oxidative stress as evident by increased malondialdehyde level and decreased antioxidant defense including glutathione and superoxide dismutase activity in rat liver, kidney and brain. AChE activity was found significantly decreased in the Tz treated groups as compared to the vehicle control (DMSO) group. Histopathological examination of liver, kidney and brain in Tz treated rats revealed medullary congestion and hydropic degeneration of hepatocytes in liver and medullary congestion in kidney. However, no significant histopathological changes were observed in brain tissues.
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