神经科学
纹状体
基底神经节
直接运动途径
大脑皮层
背
生物
断开
皮质(解剖学)
中棘神经元
神经网络
中枢神经系统
解剖
多巴胺
政治学
法学
作者
Houri Hintiryan,Nicholas N. Foster,Ian Bowman,Maxwell Bay,Monica Y. Song,Lin Gou,Seita Yamashita,Michael S. Bienkowski,Brian Zingg,Muye Zhu,Xiangdong Yang,Jean C. Shih,Arthur W. Toga,Hong‐Wei Dong
摘要
Different cortical areas are organized into distinct intracortical subnetworks. The manner in which descending pathways from the entire cortex interact subcortically as a network remains unclear. We developed an open-access comprehensive mesoscale mouse cortico-striatal projectome: a detailed connectivity projection map from the entire cerebral cortex to the dorsal striatum or caudoputamen (CP) in rodents. On the basis of these projections, we used new computational neuroanatomical tools to identify 29 distinct functional striatal domains. Furthermore, we characterized different cortico-striatal networks and how they reconfigure across the rostral-caudal extent of the CP. The workflow was also applied to select cortico-striatal connections in two different mouse models of disconnection syndromes to demonstrate its utility for characterizing circuitry-specific connectopathies. Together, our results provide the structural basis for studying the functional diversity of the dorsal striatum and disruptions of cortico-basal ganglia networks across a broad range of disorders.
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