Wnt信号通路
小核仁RNA
癌变
基因敲除
癌症研究
生物
连环素
长非编码RNA
肝细胞癌
核糖核酸
下调和上调
细胞生长
细胞周期
表型
细胞生物学
细胞
细胞凋亡
信号转导
癌症
遗传学
基因
作者
Haitao Wang,Pei Ma,Pengpeng Liu,Baiyang Chen,Zhisu Liu
标识
DOI:10.1016/j.bbrc.2018.04.074
摘要
Emerging evidence suggests that small nucleolar RNAs (snoRNAs) have malfunctioning roles in oncogenesis. In the present study, we investigated the role of box C/D small nucleolar RNA U2_19 (snoU2_19) in the tumorigenesis of hepatocellular carcinoma (HCC). Recently, we screened snoRNAs differential signatures by performing high-throughput small RNA sequence in HCC tissues and validated that upregulated snoU2_19 was associated with aggressive phenotypes in HCC patients. Aberrant snoU2_19 facilitated HCC cell proliferation, inhibited apoptosis and induced cell cycle progression in vitro analyses. We globally investigated the molecular mechanisms of snoU2_19 in HCC and found that snoU2_19 knockdown inhibited Wnt/β-catenin signaling pathway through inducing the translocation of β-catenin in cytoplasm. We concluded that snoU2_19 plays a pathological role in the development and progression of HCC, and is a potential therapeutic target for HCC.
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