Cutaneous Morbidity Among Inflammatory Bowel Disease Patients: A Cohort Study

医学 溃疡性结肠炎 炎症性肠病 队列 内科学 优势比 胃肠病学 疾病 队列研究 克罗恩病 皮肤病科
作者
Júlia Vide,Filipa Osório,Miguel Costa‐Silva,Sofia Lopes,Filomena Azevedo,Cláudia Camila Dias,Sofia Magina,Fernando Magro
出处
期刊:Journal of Crohn's and Colitis [Oxford University Press]
卷期号:12 (4): 442-451 被引量:17
标识
DOI:10.1093/ecco-jcc/jjx178
摘要

Patients with inflammatory bowel diseases are prone to cutaneous manifestations. The aim of this study was to investigate their prevalence, type and association to demographic and clinical factors. This was a cross-sectional study. Information relative to patients of a central Portuguese hospital with a definitive diagnosis of an inflammatory bowel disease, who were prospectively recruited, was collected. The final cohort included 342 patients, 62% of whom had Crohn’s disease and 38% had ulcerative colitis. Cutaneous extraintestinal manifestations were present in 44.4% of all patients; this prevalence was lower [14.9%] when excluding cutaneous manifestations secondary to nutrition deficiency or drugs. These skin lesions were classified as granulomatous [0.3%], reactive [4.4%], immunologically associated [10.5%] and secondary to nutritional deficiencies [6.4%] or to bowel-related therapy [29.5%]. Excluding those secondary to nutrition or drugs, cutaneous manifestations were significantly associated with females (odds ratio [OR] 3.210 [1.625–6.340], p = 0.001) and younger patients (OR 0.954 [0.924–0.985], p = 0.004). Additionally, their occurrence was related to patients up to 16 years (OR 13.875 [1.332–144.484], p = 0.028) among the Crohn’s disease sub-cohort, whereas in the ulcerative colitis sub-cohort they were more likely to occur in patients with extensive colitis (OR 5.317 [1.552–18.214], p = 0.008). Nearly half of the patients analysed had at least one cutaneous extraintestinal manifestation. The fact that certain lesions tend to be more common among patients with defined characteristics should alert the physicians and allow an early diagnosis and, when pertinent, a reference to dermatology.
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