阳离子聚合
两亲性
异构化
膜
抗菌剂
化学
膜透性
生物物理学
细胞膜
细菌生长
磁导率
光化学
生物化学
细菌
有机化学
生物
催化作用
聚合物
遗传学
共聚物
作者
Joana Salta,Raphael I. Benhamou,Ido M. Herzog,Micha Fridman
标识
DOI:10.1002/chem.201703010
摘要
Several important antimicrobial drugs act by permeabilizing cell membranes. In this study, we showed that the intensity of membrane permeability caused by antimicrobial cationic amphiphiles can be modified not only by their concentration but also through light-induced isomerization of their lipid segment. Two types of photo-isomerizable cationic amphiphiles were developed and the effects of photo-isomerization on bacterial growth and membrane permeability were evaluated. One photo-isomer inhibited cell growth and division, whereas the other photo-isomer led to a rapid and lethal bacterial membrane-disrupting effect. The switch from "on" to "off" can be obtained by either the cis- or trans-isomer depending on the bacterial strain and the type of cationic amphiphile. These cationic amphiphiles offer a novel tool for research and industrial applications that require light-controlled bacterial membrane permeabilization.
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