Identification of the Hippocampal Input to Medial Prefrontal Cortex In Vitro

神经科学 边缘下皮质 前额叶皮质 谷氨酸的 海马结构 内侧前脑束 兴奋性突触后电位 海马体 顺行追踪 前脑 生物 突触后电位 丘脑 抑制性突触后电位 核心 中枢神经系统 谷氨酸受体 纹状体 多巴胺 生物化学 认知 受体
作者
M Parent,Lidan Wang,Junfeng Su,Théoden I. Netoff,Li‐Lian Yuan
出处
期刊:Cerebral Cortex [Oxford University Press]
卷期号:20 (2): 393-403 被引量:140
标识
DOI:10.1093/cercor/bhp108
摘要

To delineate the cellular mechanisms underlying the function of medial prefrontal cortex (mPFC) networks, it is critical to understand how synaptic inputs from various afferents are integrated and drive neuronal activity in this region. Using a newly developed slice preparation, we were able to identify a bundle of axons that contain extraneocortical fibers projecting to neurons in the prelimbic cortex. The anatomical origin and functional connectivity of the identified fiber bundle were probed by in vivo track tracing in combination with optic and whole-cell recordings of neurons in layers 2/3 and 5/6. We demonstrate that the identified bundle contains afferent fibers primarily from the ventral hippocampus but does not include contributions from the mediodorsal nucleus of the thalamus, amygdala, or lateral hypothalamus/medial forebrain bundle. Further, we provide evidence that activation of this fiber bundle results in patterned activity of neurons in the mPFC, which is distinct from that of laminar stimulation of either the deep layers 5/6 or the superficial layer 1. Evoked excitatory postsynaptic potentials are monosynaptic and glutamatergic and exhibit bidirectional changes in synaptic efficacy in response to physiologically relevant induction protocols. These data provide the necessary groundwork for the characterization of the hippocampal pathway projecting to the mPFC.

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