Dyslipidemia and Kidney Stone Risk

No AccessJournal of UrologyUrological Survey1 Mar 2014Dyslipidemia and Kidney Stone Risk Fabio Cesar Miranda Torricelli, Shubha K. De, Surafel Gebreselassie, Ina Li, Carl Sarkissian, and Manoj Monga Fabio Cesar Miranda TorricelliFabio Cesar Miranda Torricelli Cleveland Clinic, Cleveland, Ohio More articles by this author , Shubha K. DeShubha K. De Cleveland Clinic Foundation, Cleveland Clinic, Cleveland, Ohio More articles by this author , Surafel GebreselassieSurafel Gebreselassie Department of Nephrology and Hypertension, Cleveland Clinic, Cleveland, Ohio More articles by this author , Ina LiIna Li Cleveland Clinic, Cleveland, Ohio More articles by this author , Carl SarkissianCarl Sarkissian Cleveland Clinic, Cleveland, Ohio More articles by this author , and Manoj MongaManoj Monga Stevan B. Streem Center for Endourology and Stone Disease, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2013.09.022AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We studied the impact of dyslipidemia on 24-hour urinalysis and stone composition. Materials and Methods: We retrospectively identified patients with nephrolithiasis who underwent 24-hour urinalysis and lipid profile evaluation within 3 months. Patients were divided into groups based on total cholesterol, high density lipoprotein, nonhigh density lipoprotein and triglycerides. The groups were compared based on demographic data, diabetes, hypertension and each component of 24-hour urinalysis and stone composition. Multivariate analysis and linear regression were performed to control for potential confounders, including age, gender, body mass index, diabetes and hypertension. Results: A total of 2,442 patients with a mean age of 51.1 years were included in study. On multivariate analysis patients with high total cholesterol had significantly higher urinary potassium and calcium, those with low high density lipoprotein or high triglycerides had significantly higher urinary sodium, oxalate and uric acid with lower pH, and those with high nonhigh density lipoprotein had higher urinary sodium and uric acid. Regarding stone composition, high total cholesterol and triglycerides were significantly associated with a higher uric acid stone rate (p = 0.006 and <0.001, respectively). Linear regression showed a significant association of nonhigh density lipoprotein with higher urinary sodium (p = 0.011) and uric acid (p <0.001) as well as triglycerides and higher uric acid (p = 0.017), and lower urinary pH (p = 0.005). Conclusions: There is a link between dyslipidemia and kidney stone risk that is independent of other components of metabolic syndrome such as diabetes and obesity. Specific alterations in the patient lipid profiles may portend unique aberrations in urine physicochemistry and stone risk. References 1 : Clinical review. Kidney stones 2012: pathogenesis, diagnosis, and management. J Clin Endocrinol Metab2012; 97: 1847. Google Scholar 2 : Race, ethnicity and urolithiasis: a critical review. Urolithiasis2013; 41: 99. Google Scholar 3 : Kidney stone disease: pathophysiology, investigation and medical treatment. Clin Med2012; 12: 467. Google Scholar 4 : Association between body mass index, lipid profiles, and types of urinary stones. Ren Fail2012; 34: 1140. 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De Cleveland Clinic Foundation, Cleveland Clinic, Cleveland, Ohio More articles by this author Surafel Gebreselassie Department of Nephrology and Hypertension, Cleveland Clinic, Cleveland, Ohio More articles by this author Ina Li Cleveland Clinic, Cleveland, Ohio More articles by this author Carl Sarkissian Cleveland Clinic, Cleveland, Ohio More articles by this author Manoj Monga Stevan B. Streem Center for Endourology and Stone Disease, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio More articles by this author Expand All Advertisement PDF downloadLoading ...