光热治疗
纳米材料
纳米技术
材料科学
带隙
光催化
兴奋剂
半导体
光热效应
化学
光电子学
催化作用
生物化学
作者
Xin Liu,Baiyan Sui,Pedro H. C. Camargo,Jiale Wang,Jiao Sun
标识
DOI:10.1016/j.apmt.2021.101027
摘要
Due to the complexity and heterogeneity of tumors, the therapeutic effectiveness of monomodal phototherapy is still limited. As aggressive tumors become more vulnerable to ferroptosis, synergistic ferroptosis/phototherapy has recently emerged as a promising noninvasive anti-cancer strategy. However, desirable phototherapeutic materials exhibiting altogether the required properties including excellent photothermal/photocatalytic performance, long-term biosafety and ferroptosis-inducing capability remains challenging. Herein, the present study proposed a novel strategy to construct a multifunctional nanoplatform based on band gap engineering of semiconductor nanomaterials for synergistic phototherapy. Specifically, a novel alkali-metal doped δ-MnO2 nanoflower with tunable band gap and controllable degradability was developed to realize a highly efficient and safe synergistic ferroptosis/photothermal/photocatalytic therapy. The desirable near-infrared light (NIR)-excited photothermal/photocatalytic properties of MnO2 nanoflowers were endowed and enhanced by narrowing band gap via increasing the doping alkali metal ionic radius (Mg2+
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