Resolving heterogeneity in schizophrenia through a novel systems approach to brain structure: individualized structural covariance network analysis

精神分裂症(面向对象编程) 协方差 心理学 神经科学 网络分析 计算机科学 精神科 统计 数学 量子力学 物理
作者
Zhaowen Liu,Lena Palaniyappan,Xinran Wu,Kai Zhang,Jiangnan Du,Qi Zhao,Chao Xie,Yingying Tang,Wenjun Su,Yarui Wei,Kangkang Xue,Shaoqiang Han,Shih‐Jen Tsai,Ching‐Po Lin,Jingliang Cheng,Chunbo Li,Jijun Wang,Barbara J. Sahakian,Trevor W. Robbins,Jie Zhang
出处
期刊:Molecular Psychiatry [Springer Nature]
卷期号:26 (12): 7719-7731 被引量:91
标识
DOI:10.1038/s41380-021-01229-4
摘要

Reliable mapping of system-level individual differences is a critical first step toward precision medicine for complex disorders such as schizophrenia. Disrupted structural covariance indicates a system-level brain maturational disruption in schizophrenia. However, most studies examine structural covariance at the group level. This prevents subject-level inferences. Here, we introduce a Network Template Perturbation approach to construct individual differential structural covariance network (IDSCN) using regional gray-matter volume. IDSCN quantifies how structural covariance between two nodes in a patient deviates from the normative covariance in healthy subjects. We analyzed T1 images from 1287 subjects, including 107 first-episode (drug-naive) patients and 71 controls in the discovery datasets and established robustness in 213 first-episode (drug-naive), 294 chronic, 99 clinical high-risk patients, and 494 controls from the replication datasets. Patients with schizophrenia were highly variable in their altered structural covariance edges; the number of altered edges was related to severity of hallucinations. Despite this variability, a subset of covariance edges, including the left hippocampus-bilateral putamen/globus pallidus edges, clustered patients into two distinct subgroups with opposing changes in covariance compared to controls, and significant differences in their anxiety and depression scores. These subgroup differences were stable across all seven datasets with meaningful genetic associations and functional annotation for the affected edges. We conclude that the underlying physiology of affective symptoms in schizophrenia involves the hippocampus and putamen/pallidum, predates disease onset, and is sufficiently consistent to resolve morphological heterogeneity throughout the illness course. The two schizophrenia subgroups identified thus have implications for the nosology and clinical treatment.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
2秒前
李贾美发布了新的文献求助10
3秒前
小马甲应助kaida采纳,获得10
3秒前
楼北完成签到,获得积分10
3秒前
章鱼完成签到,获得积分10
3秒前
爸爸完成签到,获得积分10
3秒前
3秒前
3秒前
豆豆发布了新的文献求助10
4秒前
哎呦喂发布了新的文献求助10
4秒前
英俊的铭应助文静的听荷采纳,获得10
4秒前
4秒前
cc发布了新的文献求助10
4秒前
良夜发布了新的文献求助10
5秒前
岛屿完成签到,获得积分20
5秒前
研白完成签到 ,获得积分10
5秒前
6秒前
superbada完成签到,获得积分10
6秒前
TT发布了新的文献求助10
6秒前
FashionBoy应助怡然的飞风采纳,获得10
6秒前
林俊杰完成签到,获得积分10
7秒前
ding应助小乔采纳,获得10
7秒前
张三完成签到,获得积分10
7秒前
8秒前
8秒前
8秒前
啦啦啦发布了新的文献求助10
9秒前
spoon1026发布了新的文献求助10
9秒前
隐形曼青应助AMM采纳,获得10
9秒前
程程完成签到,获得积分10
10秒前
10秒前
Nierdory发布了新的文献求助10
10秒前
mao完成签到,获得积分10
11秒前
xwh完成签到,获得积分10
11秒前
Deerlu完成签到,获得积分10
11秒前
Jouleken完成签到,获得积分10
11秒前
11秒前
xxq完成签到,获得积分10
12秒前
superbada发布了新的文献求助10
12秒前
12秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
A new approach to the extrapolation of accelerated life test data 1000
徐淮辽南地区新元古代叠层石及生物地层 500
Robot-supported joining of reinforcement textiles with one-sided sewing heads 400
北师大毕业论文 基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 390
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4023175
求助须知:如何正确求助?哪些是违规求助? 3563272
关于积分的说明 11341846
捐赠科研通 3294815
什么是DOI,文献DOI怎么找? 1814780
邀请新用户注册赠送积分活动 889460
科研通“疑难数据库(出版商)”最低求助积分说明 812964