Progress on Biological Activity Study and Enantioselective Synthesis of Sulfoxides

化学 对映选择合成 组合化学 有机化学 催化作用
作者
Haimeng Zhu,Chao Wang,Lili Zong
出处
期刊:Chinese Journal of Organic Chemistry [Shaghai Institute of Organic Chemistry]
卷期号:41 (9): 3431-3431 被引量:7
标识
DOI:10.6023/cjoc202103046
摘要

Sulfoxide compounds bearing unique sulfinyl group have attracted extensive attentions due to their important application in asymmetric organic synthesis and medicinal chemistry.The utility of chiral sulfoxides as versatile auxiliaries, ligands, and catalysts and synthons has been well demonstrated.Furthermore, the sulfinyl moiety can act as a pharmaceutical core, a bioisosteric replacement of the carbonyl moiety or a modifier in drug design and drug development.In this review, their biological activities with esomeprazole, ajoene, sulforaphane, sulforaphene, cenicriviroc, arbidol sulfoxide, armodafinil and so on are exemplified.And their mechanisms of action are illustrated briefly.Since the sulfur chirality is different from carbon stereogenic center, much effort has been devoted to the preparation of chiral sulfoxides.Herein the advances in asymmetric synthesis of sulfoxide during the past decade are presented.The direct asymmetric oxidation of prochiral sulfides with cheap iron-complex catalyst, polyoxometalates, organocatalyst, biocatalyst and electrocatalyst is discussed.Moreover, the complementary strategy based on sulfenate anions and miscellaneous strategies emerged recently are described.Additionally, our recent research works in the construction of chiral sulfoxide are also mentioned.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
重要山彤完成签到 ,获得积分10
1秒前
1秒前
1秒前
文静发布了新的文献求助10
2秒前
甜甜秋荷发布了新的文献求助10
2秒前
3秒前
辰月贰拾完成签到,获得积分10
4秒前
海鸟和鱼发布了新的文献求助10
5秒前
阿悦完成签到 ,获得积分10
5秒前
Hello应助超级mxl采纳,获得10
5秒前
Jasper应助科研通管家采纳,获得10
6秒前
研友_VZG7GZ应助科研通管家采纳,获得10
6秒前
小马甲应助科研通管家采纳,获得10
6秒前
深情安青应助科研通管家采纳,获得10
6秒前
JHGG应助科研通管家采纳,获得10
6秒前
6秒前
天天快乐应助科研通管家采纳,获得10
6秒前
搜集达人应助科研通管家采纳,获得10
6秒前
搜集达人应助科研通管家采纳,获得10
6秒前
benben055应助科研通管家采纳,获得20
6秒前
6秒前
JamesPei应助科研通管家采纳,获得30
7秒前
7秒前
JHGG应助科研通管家采纳,获得10
7秒前
成7应助科研通管家采纳,获得10
7秒前
小蘑菇应助科研通管家采纳,获得10
7秒前
娟儿发布了新的文献求助10
7秒前
小王要努力应助缥缈冥采纳,获得10
8秒前
学术刘亦菲关注了科研通微信公众号
9秒前
9秒前
木刻青、发布了新的文献求助30
9秒前
10秒前
奋斗蝴蝶完成签到,获得积分10
10秒前
亵渎完成签到,获得积分10
12秒前
12秒前
Kate完成签到,获得积分10
13秒前
13秒前
simpleblue发布了新的文献求助10
14秒前
海鸟和鱼完成签到,获得积分10
14秒前
14秒前
高分求助中
Impact of Mitophagy-Related Genes on the Diagnosis and Development of Esophageal Squamous Cell Carcinoma via Single-Cell RNA-seq Analysis and Machine Learning Algorithms 2000
How to Create Beauty: De Lairesse on the Theory and Practice of Making Art 1000
Gerard de Lairesse : an artist between stage and studio 670
大平正芳: 「戦後保守」とは何か 550
2019第三届中国LNG储运技术交流大会论文集 500
Contributo alla conoscenza del bifenile e dei suoi derivati. Nota XV. Passaggio dal sistema bifenilico a quello fluorenico 500
Multiscale Thermo-Hydro-Mechanics of Frozen Soil: Numerical Frameworks and Constitutive Models 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 2998259
求助须知:如何正确求助?哪些是违规求助? 2658819
关于积分的说明 7197938
捐赠科研通 2294325
什么是DOI,文献DOI怎么找? 1216550
科研通“疑难数据库(出版商)”最低求助积分说明 593547
版权声明 592904