Comparative insights into the integration mechanism of neuropeptides to starvation and temperature stress

Stress is known as the process of biological responses evoked by internal or external stimuli. The ability to sense, integrate and respond to stress signals is a requisite for life. Temperature and photoperiod are very important environmental factors for animals. In addition, stress signals can also be inputted from peripheral tissue, such as starvation and inflammation. Through afferent pathways, stress signals input to the central nervous system (CNS), where various signals will integrate, and the integrated information will transmit to the peripheral effectors. As the regulators of neural activity, neuropeptides play important roles in these processes. The present review summarizes recent findings about the integration mechanism of stress signals in the CNS, emphasizing on the role of neuropeptides.