Circulating fatty acids and risk of gestational diabetes mellitus: prospective analyses in China

妊娠期糖尿病 内科学 医学 胰岛素抵抗 怀孕 多不饱和脂肪酸 脂联素 内分泌学 妊娠期 糖尿病 瘦素 前瞻性队列研究 脂肪酸 优势比 产科 生物 肥胖 生物化学 遗传学
作者
Xiong‐Fei Pan,Yichao Huang,Xinping Li,Yi Wang,Yi Ye,Huan Chen,Matti Marklund,Ying Wen,Yan Liu,Huayan Zeng,Xiaorong Qi,Xue Yang,Chunxia Yang,Ge Liu,Robert A. Gibson,Shunqing Xu,Danxia Yu,Da Chen,Yuanyuan Li,Zhixiong Mei,An Pan,Jason Wu
出处
期刊:European journal of endocrinology [Oxford University Press]
卷期号:185 (1): 87-97 被引量:37
标识
DOI:10.1530/eje-21-0118
摘要

We aimed to examine prospective associations between circulating fatty acids in early pregnancy and incident gestational diabetes mellitus (GDM) among Chinese pregnant women.Analyses were based on two prospective nested case-control studies conducted in western China (336 GDM cases and 672 matched controls) and central China (305 cases and 305 matched controls). Fasting plasma fatty acids in early pregnancy (gestational age at enrollment: 10.4 weeks(s.d., 2.0)) and 13.2 weeks (1.0), respectively) were determined by gas chromatography-mass spectrometry, and GDM was diagnosed based on the International Association of Diabetes in Pregnancy Study Groups criteria during 24-28 weeks of gestation. Multiple metabolic biomarkers (HOMA-IR (homeostatic model assessment for insulin resistance), HbA1c, c-peptide, high-sensitivity C-reactive protein, adiponectin, leptin, and blood lipids) were additionally measured among 672 non-GDM controls at enrollment.Higher levels of saturated fatty acids (SFAs) 14:0 (pooled odds ratio, 1.41 for each 1-s.d. increase; 95% CI: 1.25, 1.59) and 16:0 (1.19; 1.05, 1.35) were associated with higher odds of GDM. Higher levels of n-6 polyunsaturated fatty acid (PUFA) 18:2n-6 were strongly associated with lower odds of GDM (0.69; 0.60, 0.80). In non-GDM pregnant women, higher SFAs 14:0 and 16:0 but lower n-6 PUFA 18:2n-6 were generally correlated with unfavorable metabolic profiles.We documented adverse associations of 14:0 and 16:0 but a protective association of 18:2n-6 with GDM among Chinese pregnant women. Our findings highlight the distinct roles of specific fatty acids in the onset of GDM.
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