Association of heart rate and diabetes among 0.5 million adults in the China Kadoorie biobank: Results from observational and Mendelian randomization analyses

孟德尔随机化 医学 比例危险模型 生命银行 糖尿病 观察研究 2型糖尿病 内科学 单核苷酸多态性 人口学 置信区间 危险系数 内分泌学 生物信息学 遗传学 生物 遗传变异 社会学 基因型 基因
作者
Wenxiu Wang,Jingjia Wang,Jun Lv,Canqing Yu,Chunli Shao,Yi‐Da Tang,Yu Guo,Bin Zheng,Huaidong Du,Ling Yang,Iona Y. Millwood,Robin Walters,Yiping Chen,Liang Chang,Lei Fan,Junshi Chen,Zhengming Chen,Tao Huang,Liming Li,Junshi Chen,Zhengming Chen,Robert Clarke,Rory Collins,Yu Guo,Liming Li,Jun Lv,Richárd Pető,Robin Walters,Daniel Avery,Ruth Boxall,Derrick Bennett,Yu‐Mei Chang,Yiping Chen,Zhengming Chen,Robert Clarke,Huaidong Du,Simon Gilbert,Alex Hacker,Mike Hill,Michael V. Holmes,Andri Iona,Christiana Kartsonaki,Rene Kerosi,Ling Kong,Om Kurmi,Garry Lancaster,Sarah Lewington,Keqin Lin,J. A. M. McDonnell,Iona Y. Millwood,Qunhua Nie,Jayakrishnan Radhakrishnan,Paul Ryder,Sam Sansome,Dan Schmidt,Paul Sherliker,Rajani Sohoni,Becky Stevens,Iain Turnbull,Robin G. Walters,Jenny Wang,Lin Wang,Neil Wright,Ling Yang,Xiaoming Yang,Bin Zheng,Yu Guo,Xiao Han,Chenping Hou,Jun Lv,Pei Pei,Chao Liu,Yunlong Tan,Canqing Yu,Zengchang Pang,Ruqin Gao,Shanpeng Li,Shaojie Wang,Yongmei Liu,Ranran Du,Yajing Zang,Liang Cheng,Xiaocao Tian,Hua Zhang,Yaoming Zhai,Na Feng,Xiaotao Sun,Feifei Li,Silu Lv,Junzheng Wang,Wei Hou,Mingyuan Zeng,Jian Ge,Xin‐Da Zhou,Lucy Yang,Hua He,Bo Yu,Yanjie Li,Qinai Xu,Qi Kang,Ziyan Guo,Dan Wang,Xiaoyi Hu,Jinyan Chen,Yan Fu,Zhenwang Fu,Xiaohuan Wang,Min Wang,Zhendong Guo,Shukuan Wu,Yilei Li,Huimei Li,Zhanli Fu,Ming Wu,Yonglin Zhou,Jinyi Zhou,Ran Tao,Jie Yang,Jian Su,Fang Liu,Jun Zhang,Yihe Hu,Yan Lü,Liangcai Ma,Aiyu Tang,Shuo Zhang,Jianrong Jin,Jingchao Liu,Zhenzhu Tang,Naying Chen,Ying Huang,Mingqiang Li,Jia Meng,Rong Pan,Qilian Jiang,Jian Lan,Yun Liu,Liuping Wei,Liyuan Zhou,Ningyu Chen Ping Wang,Fanwen Meng,Yulu Qin,Sisi Wang,Xianping Wu,Ningmei Zhang,Xiaofang Chen,Weiwei Zhou,Guojin Luo,Jianguo Li,Xiaofang Chen,Xunfu Zhong,Jiaqiu Liu,Qiang Sun,Pengfei Ge,Xiaolan Ren,Caixia Dong,Dongliang Zhang,Enke Mao,Xiaoping Wang,Tao Wang,Xi Zhang,Zhongxiang Ding,Gang Zhou,Feng Shi,Liang Chang,Lei Fan,Yulian Gao,Tengbing He,Huarong Sun,Ping He,Chen Hu,Xukui Zhang,Huifang Wu,Ping He,Miao Yu,Ruying Hu,Hao Wang,Yijian Qian,Chunmei Wang,Kaixu Xie,Lingli Chen,Yidan Zhang,Dongxia Pan,Qijun Gu,Yanqing Huang,Biyun Chen,Li Yin,Huilin Liu,Zhongxi Fu,Qi Xu,Xin Xu,Hao Zhang,Huajun Long,Xianzhi Li,Libo Zhang,Zhe Qiu
出处
期刊:Nutrition Metabolism and Cardiovascular Diseases [Elsevier]
卷期号:31 (8): 2328-2337 被引量:4
标识
DOI:10.1016/j.numecd.2021.04.015
摘要

Background and aims Observational studies have associated resting heart rate with incident diabetes. Whether the associations are causal remains unclear. We aimed to examine the shape and strength of the associations and assessed the causal relevance of such associations in Chinese adults. Methods and results The China Kadoorie Biobank enrolled 512,891 adults in China. Cox proportional hazard regression models was conducted to estimate hazard ratios (HRs) for the associations of resting heart rate with type 2 diabetes and total diabetes. Among 92,724 participants, 36 single-nucleotide polymorphisms (SNPs) related to resting heart rate were used to construct genetic risk score. We used Mendelian randomization analyses to make the causal inferences. During a median follow-up of 9 years, 7872 incident type 2 diabetes and 13,349 incident total diabetes were documented. After regression dilution bias adjustment, each 10 bpm higher heart rate was associated with about a 26% higher risk of type 2 diabetes (HR, 1.26 [95% CI, 1.23, 1.29]) and 23% higher risk of total diabetes (HR, 1.23 [95% CI, 1.20, 1.26]). Instrumental variable analyses showed participants at top quintile compared with those at bottom quintile had 30% higher risk for type 2 diabetes (HR, 1.30 [95% CI, 1.17, 1.43]), and 10% higher risk for total diabetes (HR, 1.10 [95% CI, 1.02, 1.20]). Conclusions This study provides evidence that resting heart rate is an important risk factor for diabetes risk. The results suggest that novel treatment approaches targeting reduction of high heart rate for incidence of diabetes may be worth further investigation.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
lllwww完成签到 ,获得积分10
刚刚
3秒前
拓跋傲薇完成签到,获得积分10
5秒前
Lisztan完成签到,获得积分10
6秒前
狄绮发布了新的文献求助10
8秒前
小丑岩完成签到,获得积分10
8秒前
ZX0501完成签到,获得积分10
9秒前
Owen应助willa采纳,获得10
9秒前
HCLonely应助dsi采纳,获得10
9秒前
jkaaa完成签到,获得积分10
11秒前
14秒前
云猫完成签到 ,获得积分10
15秒前
zcydbttj2011完成签到 ,获得积分10
16秒前
17秒前
wbscz完成签到 ,获得积分10
20秒前
涨芝士完成签到 ,获得积分10
21秒前
ciiiv完成签到 ,获得积分10
23秒前
研友_LMBAXn完成签到,获得积分20
23秒前
Simpson完成签到 ,获得积分10
25秒前
dsi完成签到,获得积分10
25秒前
Kevin完成签到,获得积分10
26秒前
Andy完成签到 ,获得积分10
27秒前
都要多喝水完成签到,获得积分10
28秒前
Hello应助小鱼儿飞飞采纳,获得10
29秒前
韧迹完成签到 ,获得积分10
34秒前
36秒前
无言完成签到 ,获得积分10
39秒前
皮皮完成签到 ,获得积分10
44秒前
清浅溪完成签到 ,获得积分10
45秒前
机灵的衬衫完成签到 ,获得积分10
46秒前
吉吉完成签到 ,获得积分10
46秒前
一叶飘红完成签到,获得积分10
47秒前
jingjing完成签到,获得积分10
47秒前
铁柱xh完成签到 ,获得积分10
48秒前
大东东发布了新的文献求助10
50秒前
Kamal完成签到,获得积分10
51秒前
willa完成签到,获得积分10
51秒前
欢喜板凳完成签到 ,获得积分10
54秒前
WindDreamer完成签到,获得积分10
59秒前
MiSD完成签到,获得积分10
59秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
Write Like a Chemist: A Guide and Resource (第二版) 600
Mixed-anion Compounds 600
A new species of Velataspis (Hemiptera Coccoidea Diaspididae) from tea in Assam 500
Earth System Geophysics 500
Aspects of Babylonian celestial divination: the lunar eclipse tablets of Enūma Anu Enlil 500
Geochemistry, 2nd Edition 地球化学经典教科书第二版 401
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3200810
求助须知:如何正确求助?哪些是违规求助? 2850571
关于积分的说明 8072470
捐赠科研通 2514308
什么是DOI,文献DOI怎么找? 1347060
科研通“疑难数据库(出版商)”最低求助积分说明 640332
邀请新用户注册赠送积分活动 610520