Association of heart rate and diabetes among 0.5 million adults in the China Kadoorie biobank: Results from observational and Mendelian randomization analyses

孟德尔随机化 医学 比例危险模型 生命银行 糖尿病 观察研究 2型糖尿病 内科学 单核苷酸多态性 人口学 置信区间 危险系数 内分泌学 生物信息学 遗传学 生物 遗传变异 社会学 基因型 基因
作者
Wenxiu Wang,Jingjia Wang,Jun Lv,Canqing Yu,Chunli Shao,Yi‐Da Tang,Yu Guo,Bin Zheng,Huaidong Du,Ling Yang,Iona Y. Millwood,Robin Walters,Yiping Chen,Liang Chang,Lei Fan,Junshi Chen,Zhengming Chen,Tao Huang,Liming Li,Junshi Chen,Zhengming Chen,Robert Clarke,Rory Collins,Yu Guo,Liming Li,Jun Lv,Richárd Pető,Robin Walters,Daniel Avery,Ruth Boxall,Derrick Bennett,Yu‐Mei Chang,Yiping Chen,Zhengming Chen,Robert Clarke,Huaidong Du,Simon Gilbert,Alex Hacker,Mike Hill,Michael V. Holmes,Andri Iona,Christiana Kartsonaki,Rene Kerosi,Ling Kong,Om Kurmi,Garry Lancaster,Sarah Lewington,Keqin Lin,J. A. M. McDonnell,Iona Y. Millwood,Qunhua Nie,Jayakrishnan Radhakrishnan,Paul Ryder,Sam Sansome,Dan Schmidt,Paul Sherliker,Rajani Sohoni,Becky Stevens,Iain Turnbull,Robin G. Walters,Jenny Wang,Lin Wang,Neil Wright,Ling Yang,Xiaoming Yang,Bin Zheng,Yu Guo,Xiao Han,Chenping Hou,Jun Lv,Pei Pei,Chao Liu,Yunlong Tan,Canqing Yu,Zengchang Pang,Ruqin Gao,Shanpeng Li,Shaojie Wang,Yongmei Liu,Ranran Du,Yajing Zang,Liang Cheng,Xiaocao Tian,Hua Zhang,Yaoming Zhai,Na Feng,Xiaotao Sun,Feifei Li,Silu Lv,Junzheng Wang,Wei Hou,Mingyuan Zeng,Jian Ge,Xin‐Da Zhou,Lucy Yang,Hua He,Bo Yu,Yanjie Li,Qinai Xu,Qi Kang,Ziyan Guo,Dan Wang,Xiaoyi Hu,Jinyan Chen,Yan Fu,Zhenwang Fu,Xiaohuan Wang,Min Wang,Zhendong Guo,Shukuan Wu,Yilei Li,Huimei Li,Zhanli Fu,Ming Wu,Yonglin Zhou,Jinyi Zhou,Ran Tao,Jie Yang,Jian Su,Fang Liu,Jun Zhang,Yihe Hu,Yan Lü,Liangcai Ma,Aiyu Tang,Shuo Zhang,Jianrong Jin,Jingchao Liu,Zhenzhu Tang,Naying Chen,Ying Huang,Mingqiang Li,Jia Meng,Rong Pan,Qilian Jiang,Jian Lan,Yun Liu,Liuping Wei,Liyuan Zhou,Ningyu Chen Ping Wang,Fanwen Meng,Yulu Qin,Sisi Wang,Xianping Wu,Ningmei Zhang,Xiaofang Chen,Weiwei Zhou,Guojin Luo,Jianguo Li,Xiaofang Chen,Xunfu Zhong,Jiaqiu Liu,Qiang Sun,Pengfei Ge,Xiaolan Ren,Caixia Dong,Dongliang Zhang,Enke Mao,Xiaoping Wang,Tao Wang,Xi Zhang,Zhongxiang Ding,Gang Zhou,Feng Shi,Liang Chang,Lei Fan,Yulian Gao,Tengbing He,Huarong Sun,Ping He,Chen Hu,Xukui Zhang,Huifang Wu,Ping He,Miao Yu,Ruying Hu,Hao Wang,Yijian Qian,Chunmei Wang,Kaixu Xie,Lingli Chen,Yidan Zhang,Dongxia Pan,Qijun Gu,Yanqing Huang,Biyun Chen,Li Yin,Huilin Liu,Zhongxi Fu,Qi Xu,Xin Xu,Hao Zhang,Huajun Long,Xianzhi Li,Libo Zhang,Zhe Qiu
出处
期刊:Nutrition Metabolism and Cardiovascular Diseases [Elsevier]
卷期号:31 (8): 2328-2337 被引量:4
标识
DOI:10.1016/j.numecd.2021.04.015
摘要

Background and aims Observational studies have associated resting heart rate with incident diabetes. Whether the associations are causal remains unclear. We aimed to examine the shape and strength of the associations and assessed the causal relevance of such associations in Chinese adults. Methods and results The China Kadoorie Biobank enrolled 512,891 adults in China. Cox proportional hazard regression models was conducted to estimate hazard ratios (HRs) for the associations of resting heart rate with type 2 diabetes and total diabetes. Among 92,724 participants, 36 single-nucleotide polymorphisms (SNPs) related to resting heart rate were used to construct genetic risk score. We used Mendelian randomization analyses to make the causal inferences. During a median follow-up of 9 years, 7872 incident type 2 diabetes and 13,349 incident total diabetes were documented. After regression dilution bias adjustment, each 10 bpm higher heart rate was associated with about a 26% higher risk of type 2 diabetes (HR, 1.26 [95% CI, 1.23, 1.29]) and 23% higher risk of total diabetes (HR, 1.23 [95% CI, 1.20, 1.26]). Instrumental variable analyses showed participants at top quintile compared with those at bottom quintile had 30% higher risk for type 2 diabetes (HR, 1.30 [95% CI, 1.17, 1.43]), and 10% higher risk for total diabetes (HR, 1.10 [95% CI, 1.02, 1.20]). Conclusions This study provides evidence that resting heart rate is an important risk factor for diabetes risk. The results suggest that novel treatment approaches targeting reduction of high heart rate for incidence of diabetes may be worth further investigation.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
无花果应助鳗鱼新之采纳,获得10
刚刚
botanist完成签到 ,获得积分10
1秒前
华仔应助贾克斯采纳,获得10
1秒前
古古发布了新的文献求助10
2秒前
TYM发布了新的文献求助10
3秒前
海上森林的一只猫完成签到 ,获得积分10
3秒前
FashionBoy应助tianguoheng采纳,获得10
4秒前
4秒前
5秒前
7秒前
8秒前
Annie发布了新的文献求助10
9秒前
11秒前
TYM发布了新的文献求助10
12秒前
爆米花应助Demon724采纳,获得20
14秒前
CipherSage应助郜雨寒采纳,获得10
14秒前
可爱的函函应助郜雨寒采纳,获得10
14秒前
爆米花应助郜雨寒采纳,获得10
14秒前
丘比特应助郜雨寒采纳,获得10
14秒前
汉堡包应助郜雨寒采纳,获得10
15秒前
FashionBoy应助郜雨寒采纳,获得10
15秒前
lulu完成签到,获得积分10
15秒前
科研通AI2S应助郜雨寒采纳,获得10
15秒前
Billy应助郜雨寒采纳,获得10
15秒前
科研小白白应助郜雨寒采纳,获得30
15秒前
彭于晏应助郜雨寒采纳,获得10
15秒前
清明发布了新的文献求助10
15秒前
16秒前
顺心绝山发布了新的文献求助10
17秒前
酷波er应助喜悦采纳,获得10
18秒前
瘦瘦雅香应助如意友灵采纳,获得10
18秒前
felix发布了新的文献求助10
19秒前
24秒前
24秒前
hugo完成签到,获得积分20
26秒前
26秒前
28秒前
29秒前
29秒前
李至安发布了新的文献求助10
30秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
2-Acetyl-1-pyrroline: an important aroma component of cooked rice 500
A real-time energy management strategy based on fuzzy control and ECMS for PHEVs 400
Handbook on People's China (1957) 400
2024 Medicinal Chemistry Reviews 400
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3189606
求助须知:如何正确求助?哪些是违规求助? 2838957
关于积分的说明 8022163
捐赠科研通 2501783
什么是DOI,文献DOI怎么找? 1336042
科研通“疑难数据库(出版商)”最低求助积分说明 637750
邀请新用户注册赠送积分活动 605820