Evaluation of suspicious breast lesions with diffusion kurtosis MR imaging and connection with prognostic factors

医学 接收机工作特性 曼惠特尼U检验 有效扩散系数 乳房磁振造影 磁共振弥散成像 淋巴结 乳腺癌 放射科 机构审查委员会 核医学 磁共振成像 乳腺摄影术 内科学 癌症 外科
作者
Zhen Yang,Yan Li,Chen Ao Zhan,Yi Hu,Yi Guo,Xia Li,Tao Ai
出处
期刊:European Journal of Radiology [Elsevier]
卷期号:145: 110014-110014 被引量:11
标识
DOI:10.1016/j.ejrad.2021.110014
摘要

To investigate the additional value of DKI in discriminating suspicious breast lesions on DCE-MRI, as compared with conventional DWI; and to explore connection between DKI-parameters and prognostic factors of breast cancers.The institutional review board approved this retrospective study and written informed consent was waived. Totally, 300 women (mean age, 43.2 ± 10.4 years) with suspicious breast lesions on DCE-MRI were enrolled from November 2014 to September 2019. With pathology as reference, performance of ADC, Kapp and Dapp in discriminating suspicious breast lesions were analyzed by receiver operating characteristic (ROC) analysis with area under ROC curve (AUC). The specificities of parameters were compared by Chi-square test. The ADC, Kapp and Dapp of breast cancers with different receptor status were compared using Student's t or Mann-Whitney U or Kruskal-Wallis test.There were 344 suspicious breast lesions (220 malignant, 124 benign) in 300 women. No significant differences were found for AUCs of ADC and DKI-parameters in discriminating suspicious breast lesions (0.882 vs. 0.888, p = 0.480). The specificities were significantly higher with ADC and Dapp than that with DCE-MRI (p = 0.003 and 0.005). The ADC, Kapp and Dapp were correlated with HER2 expression and lymph node status, and ADC and Kapp differed between ER-positive and negative tumors (all p < 0.05). Except Kapp, DKI/DWI-parameters showed relation with Ki-67 expression. None of the DKI/DWI-parameters showed relation with lesion grade (all p > 0.05).The more complicated and time-consuming DKI is not superior to conventional DWI in differentiating suspicious breast lesions and reflecting prognostic information of breast cancer.
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