亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

SURG-03. FUNCTIONAL OUTCOMES OF LASER INTERSTITIAL THERMAL THERAPY (LITT) VERSUS RESECTION IN THE TREATMENT OF LESIONS IN OR NEAR THE PRIMARY MOTOR CORTEX

医学 外科 回顾性队列研究 队列 坏死 切除术 内科学
作者
E. Srinivasan,Emily Lerner,Ryan Edwards,David Huie,Peter E. Fecci
出处
期刊:Neuro-oncology [Oxford University Press]
卷期号:23 (Supplement_6): vi195-vi195
标识
DOI:10.1093/neuonc/noab196.773
摘要

Abstract INTRODUCTION Laser interstitial thermal therapy (LITT) is a minimally-invasive treatment option for radiographically-progressive (RP) brain metastases. This study compares the functional outcomes of LITT vs resection (RS) for lesions in or near the primary motor cortex (PMC). METHODS Retrospective review was performed of patients treated for PMC lesions by LITT or RS. Functional outcomes were graded relative to pre-treatment symptoms and categorized as improved, stable, or worsened at 30, 90, and 180 days post-LITT/RS. RESULTS 36 patients were identified with median follow-up of 194 days (IQR 72-503), age 64 years (57-72), and estimated baseline KPS 80 (80-90). 35 (98%) had pre-treatment weakness or motor seizure; 15 (42%) received LITT and 21 (58%) RS; all RS were performed with intra-operative motor mapping while LITT were not. All LITT patients were treated for RP lesions (radiation necrosis (RN) or disease progression) vs. 24% of RS patients (p< 0.01). LITT patients trended towards smaller lesions (1.9 cm vs 2.7 cm, p=0.03) and were more likely to show RN (67% vs 5%, p< 0.01) and be discharged home (87% vs 52%, p=0.04), with shorter ICU (0 vs 1 day, p< 0.01) and hospital stays (1 vs. 2 days, p< 0.01). At 30 days, 89% of surviving patients who received RS had stable or improved symptoms, compared to 46% of the LITT cohort (p=0.02). At 90 days, the difference was 88% to 50% (p=0.07), and at 180 days 100% to 80% (p=0.2941). CONCLUSIONS In the short term (30 days), patients with PMC lesions have better functional outcomes when treated with RS compared to LITT, while those who survive to the 180-day timepoint experience similar outcomes. These differences are likely due to transient, expected post-LITT edema that subsides with time. Taken together, prognosis and patient priorities are important considerations in the decision between LITT and RS.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
SPLjoker完成签到 ,获得积分10
10秒前
Wsssss完成签到,获得积分10
12秒前
奋斗的暖阳完成签到,获得积分10
13秒前
科研通AI2S应助科研通管家采纳,获得30
18秒前
CipherSage应助科研通管家采纳,获得10
18秒前
ZL完成签到 ,获得积分10
19秒前
24秒前
Diamond完成签到 ,获得积分10
28秒前
平淡如天发布了新的文献求助10
29秒前
JamesPei应助平淡如天采纳,获得10
40秒前
余念安完成签到 ,获得积分10
45秒前
54秒前
55秒前
El发布了新的文献求助10
1分钟前
某个不想做人的dio完成签到 ,获得积分10
1分钟前
冷静新烟发布了新的文献求助10
1分钟前
Eden完成签到,获得积分10
1分钟前
1分钟前
烟花应助灵感大王喵采纳,获得200
1分钟前
夏夏完成签到 ,获得积分10
1分钟前
1分钟前
1分钟前
潘善若发布了新的文献求助10
1分钟前
田様应助El采纳,获得10
1分钟前
隔壁巷子里的劉完成签到 ,获得积分10
1分钟前
李爱国应助潘善若采纳,获得10
1分钟前
1分钟前
五十一完成签到 ,获得积分10
1分钟前
奇遇完成签到 ,获得积分10
1分钟前
2分钟前
含糊的安柏完成签到,获得积分10
2分钟前
huihongzeng发布了新的文献求助10
2分钟前
NexusExplorer应助含糊的安柏采纳,获得10
2分钟前
2分钟前
冷静新烟完成签到,获得积分20
2分钟前
冷静新烟发布了新的文献求助10
2分钟前
简单山水发布了新的文献求助10
2分钟前
Novajet完成签到,获得积分10
2分钟前
yx_cheng应助归海浩阑采纳,获得30
2分钟前
ding应助科研通管家采纳,获得10
2分钟前
高分求助中
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3990012
求助须知:如何正确求助?哪些是违规求助? 3532077
关于积分的说明 11256227
捐赠科研通 3270933
什么是DOI,文献DOI怎么找? 1805139
邀请新用户注册赠送积分活动 882270
科研通“疑难数据库(出版商)”最低求助积分说明 809228