光敏剂
血卟啉
抗菌活性
化学
结合
共轭体系
光动力疗法
纳米颗粒
猝灭(荧光)
光降解
壳聚糖
核化学
光化学
荧光
卟啉
组合化学
光催化
纳米技术
材料科学
有机化学
聚合物
细菌
催化作用
数学分析
物理
生物
量子力学
遗传学
数学
作者
Ting Zhou,Yihua Yin,Weiquan Cai,Haibo Wang,Lihong Fan,Guanghua He,Jingli Zhang,Mengqing Jiang,Jinsheng Liu
标识
DOI:10.1016/j.carbpol.2021.118242
摘要
To promote bactericidal activity, improve photostability and safety, novel antibacterial nanoparticle system based on photodynamic action (PDA) was prepared here through conjugation of photosensitizer hematoporphyrin (HP) onto carboxymethyl chitosan (CMCS) via amide linkage and followed by ultrasonic treatment. The system was stable in PBS (pH 7.4) and could effectively inhibit the photodegradation of conjugated HP because of aggregation-caused quenching effect. ROS produced by the conjugated HP under light exposure could change the structure of nanoparticles by oxidizing the CMCS skeleton and thereby significantly promote the photodynamic activity of HP and its photodynamic activity after 6 h was higher than that of HP·2HCl under the same conditions. Antibacterial experiments showed that CMCS-HP nanoparticles had excellent photodynamic antibacterial activity, and the bacterial inhibition rates after 60 min of light exposure were greater than 97%. Safety evaluation exhibited that the nanoparticles were safe to mammalian cells, showing great potential for antibacterial therapy.
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