Novel carbonic anhydrase inhibitors

碳酸酐酶 化学 梅德林 医学 图书馆学 生物信息学 生物化学 计算机科学 生物
作者
Claudiu T. Supuran
出处
期刊:Future Medicinal Chemistry [Newlands Press Ltd]
卷期号:13 (22): 1935-1937 被引量:45
标识
DOI:10.4155/fmc-2021-0222
摘要

Future Medicinal ChemistryVol. 13, No. 22 EditorialNovel carbonic anhydrase inhibitorsClaudiu T SupuranClaudiu T Supuran *Author for correspondence: E-mail Address: claudiu.supuran@unifi.ithttps://orcid.org/0000-0003-4262-0323Neurofarba Department, Pharmaceutical & Nutraceutical Section, University of Florence, Via Ugo Schiff 6, Sesto Fiorentino, Florence, 50019, ItalyPublished Online:9 Sep 2021https://doi.org/10.4155/fmc-2021-0222AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInReddit View articleKeywords: carbonic anhydraseshypoxic tumorsinhibition mechanismsinhibitorspharmacological applicationsReferences1. Supuran CT. Carbonic anhydrases: novel therapeutic applications for inhibitors and activators. Nat. Rev. Drug Discov. 7(2), 168–181 (2008).Crossref, Medline, CAS, Google Scholar2. Supuran CT. Structure and function of carbonic anhydrases. Biochem. J. 473(14), 2023–2032 (2016).Crossref, Medline, CAS, Google Scholar3. Hirakawa Y, Senda M, Fukuda K et al. Characterization of a novel type of carbonic anhydrase that acts without metal cofactors. BMC Biol. 19(1), 105 (.2021).Crossref, Medline, CAS, Google Scholar4. Supuran CT. Emerging role of carbonic anhydrase inhibitors. Clin. Sci. (Lond.) 135(10), 1233–1249 (2021).Crossref, Medline, CAS, Google Scholar5. Maren TH. Carbonic anhydrase: chemistry, physiology, and inhibition. Physiol. Rev. 47(4), 595–781 (1967).Crossref, Medline, CAS, Google Scholar6. Supuran CT. Structure-based drug discovery of carbonic anhydrase inhibitors. J. Enzyme Inhib. Med. Chem. 27(6), 759–772 (2012).Crossref, Medline, CAS, Google Scholar7. Parkkila S, Lasota J, Fletcher JA et al. Carbonic anhydrase II. A novel biomarker for gastrointestinal stromal tumors. Mod. Pathol. 23(5), 743–750 (2010).Crossref, Medline, CAS, Google Scholar8. van Karnebeek CD, Sly WS, Ross CJ et al. Mitochondrial carbonic anhydrase VA deficiency resulting from CA5A alterations presents with hyperammonemia in early childhood. Am. J. Hum. Genet. 94(3), 453–461 (2014).Crossref, Medline, CAS, Google Scholar9. Scozzafava A, Menabuoni L, Mincione F, Briganti F, Mincione G, Supuran CT. Carbonic anhydrase inhibitors. Synthesis of water-soluble, topically effective, intraocular pressure-lowering aromatic/heterocyclic sulfonamides containing cationic or anionic moieties: is the tail more important than the ring? J. Med. Chem. 42(14), 2641–2650 (1999).Crossref, Medline, CAS, Google Scholar10. Supuran CT. Exploring the multiple binding modes of inhibitors to carbonic anhydrases for novel drug discovery. Expert Opin. Drug Discov. 15(6), 671–686 (2020).Crossref, Medline, CAS, Google Scholar11. Mishra CB, Tiwari M, Supuran CT. Progress in the development of human carbonic anhydrase inhibitors and their pharmacological applications: where are we today? Med. Res. Rev. 40(6), 2485–2565 (2020).Crossref, Medline, CAS, Google Scholar12. Supuran CT. How many carbonic anhydrase inhibition mechanisms exist? J. Enzyme Inhib. Med. Chem. 31(3), 345–360 (2016).Crossref, Medline, CAS, Google Scholar13. D'Ambrosio K, Carradori S, Monti SM et al. Out of the active site binding pocket for carbonic anhydrase inhibitors. Chem. Commun. (Camb). 51(2), 302–305 (2015).Crossref, Medline, Google Scholar14. Berrino E, Michelet B, Martin-Mingot A, Carta F, Supuran CT, Thibaudeau S. Modulating the efficacy of carbonic anhydrase inhibitors through fluorine substitution. Angew. Chem. Int. Ed. Engl. 60, 2–17 (2021).Crossref, Google Scholar15. Nocentini A, Angeli A, Carta F et al. Reconsidering anion inhibitors in the general context of drug design studies of modulators of activity of the classical enzyme carbonic anhydrase. J. Enzyme Inhib. Med. Chem. 36(1), 561–580 (2021).Crossref, Medline, CAS, Google Scholar16. McDonald PC, Chia S, Bedard PL et al. A Phase 1 study of SLC-0111, a novel inhibitor of carbonic anhydrase IX, in patients with advanced solid tumors. Am. J. Clin. Oncol. 43(7), 484–490 (2020).Crossref, Medline, CAS, Google Scholar17. Dettori I, Fusco I, Bulli I et al. Protective effects of carbonic anhydrase inhibition in brain ischaemia in vitro and in vivo models. J. Enzyme Inhib. Med. Chem. 36(1), 964–976 (2021).Crossref, Medline, CAS, Google Scholar18. Provensi G, Carta F, Nocentini A et al. A new kid on the block? Carbonic anhydrases as possible new targets in Alzheimer’s disease. Int. J. Mol. Sci. 20(19), 4724 (2019).Crossref, CAS, Google Scholar19. Supuran CT, Nocentini A, Yakubova E, Savchuk N, Kalinin S, Krasavin M. Biochemical profiling of anti-HIV prodrug Elsulfavirine (Elpida®) and its active form VM1500A against a panel of twelve human carbonic anhydrase isoforms. J. Enzyme Inhib. Med. Chem. 36(1), 1056–1060 (2021).Crossref, Medline, CAS, Google Scholar20. Bua S, Lucarini L, Micheli L et al. Bioisosteric development of multitarget nonsteroidal anti-inflammatory drug-carbonic anhydrases inhibitor hybrids for the management of rheumatoid arthritis. J. Med. Chem. 63(5), 2325–2342 (2020).Crossref, Medline, CAS, Google ScholarFiguresReferencesRelatedDetails Vol. 13, No. 22 Follow us on social media for the latest updates Metrics Downloaded 194 times History Received 29 July 2021 Accepted 31 August 2021 Published online 9 September 2021 Published in print November 2021 Information© 2021 Newlands PressKeywordscarbonic anhydraseshypoxic tumorsinhibition mechanismsinhibitorspharmacological applicationsFinancial & competing interests disclosureResearch from the author’s laboratory was financed by the Italian Ministry for University and Research (MIUR), grants PRIN prot. 2017XYBP2R and FISR2019_04819 BacCAD. The author has no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.No writing assistance was utilized in the production of this manuscript.PDF download
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
懦弱的难敌发布了新的文献求助100
2秒前
2秒前
RKK完成签到,获得积分10
2秒前
2秒前
高高问夏发布了新的文献求助10
3秒前
温婉的孤兰完成签到,获得积分10
3秒前
mermaid发布了新的文献求助10
3秒前
4秒前
晨gegeai发布了新的文献求助10
5秒前
5秒前
5秒前
Zn应助silence采纳,获得10
5秒前
复杂天真完成签到 ,获得积分10
6秒前
RKK发布了新的文献求助10
6秒前
岸上牛发布了新的文献求助10
6秒前
坐看云起时完成签到 ,获得积分20
7秒前
aaronzhu1995发布了新的文献求助30
7秒前
Hello应助豌豆采纳,获得10
7秒前
小蘑菇应助苗大侠采纳,获得10
7秒前
yu发布了新的文献求助10
8秒前
CC完成签到,获得积分10
8秒前
SYLH应助一汪采纳,获得10
8秒前
yzy发布了新的文献求助10
8秒前
9秒前
XiaoYuuu完成签到,获得积分10
10秒前
10秒前
小王啵啵完成签到 ,获得积分10
10秒前
11秒前
夏山发布了新的文献求助10
11秒前
15秒前
闫磊发布了新的文献求助10
15秒前
明天过后发布了新的文献求助10
15秒前
zhilanyao发布了新的文献求助30
16秒前
爆米花应助榛苓采纳,获得10
16秒前
16秒前
16秒前
16秒前
fzd完成签到,获得积分10
16秒前
17秒前
高分求助中
Continuum Thermodynamics and Material Modelling 3000
Production Logging: Theoretical and Interpretive Elements 2700
Mechanistic Modeling of Gas-Liquid Two-Phase Flow in Pipes 2500
Kelsen’s Legacy: Legal Normativity, International Law and Democracy 1000
Conference Record, IAS Annual Meeting 1977 610
The Laschia-complex (Basidiomycetes) 600
Interest Rate Modeling. Volume 3: Products and Risk Management 600
热门求助领域 (近24小时)
化学 材料科学 生物 医学 工程类 有机化学 生物化学 物理 纳米技术 计算机科学 内科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 量子力学 光电子学 冶金
热门帖子
关注 科研通微信公众号,转发送积分 3541156
求助须知:如何正确求助?哪些是违规求助? 3118348
关于积分的说明 9335388
捐赠科研通 2816304
什么是DOI,文献DOI怎么找? 1548299
邀请新用户注册赠送积分活动 721471
科研通“疑难数据库(出版商)”最低求助积分说明 712690