Hollow tube covalent organic framework for syringe filter-based extraction of ultraviolet stabilizer in food contact materials

In this work, a novel hollow tube covalent organic framework constructed by cyclotricatechylene and tetrafluoroterephthalonitrile (CTC-TFPN-COF) with polyether bond was synthesized, and it was coated on filter membrane for extraction of ultraviolet stabilizer in migration from food contact materials. Since the monomers of the polymer were linked by polyether bond, the CTC-TFPN-COF exhibited strong chemical stability in severe conditions such as acid, alkali and various organic solvent. The excellent features of high porosity and robust structure endowed the CTC-TFPN-COF good candidate as adsorbent for extraction of ultraviolet stabilizer. Moreover, the CTC-TFPN-COF coated membranes were immobilized on syringe filter and coupled with multiple channel injection pump to realize high throughput sample pretreatment strategy. Subsequently, a sensitive analytical method for ultraviolet stabilizer was established followed by ultra-high performance liquid chromatography-tandem mass spectrometry. The flow rate of extraction and desorption, elution solvent and the volume of desorption solvent were optimized. The method was assessed, which showed wide linear ranges with R2 greater than 0.99, low limits of detection (0.9-91 ng L−1) and low limits of quantification (3-300 ng L−1). The developed method was successfully applied to determine trace ultraviolet stabilizer in the migration of food contact materials with different simulated solution, which demonstrated its promising potential in practical analysis.