Risk Signature of Cancer-Associated Fibroblast–Secreted Cytokines Associates With Clinical Outcomes of Breast Cancer

医学 内科学 肿瘤科 癌症 癌相关成纤维细胞 基因签名 生物标志物
作者
Chunxiao Sun,Siwei Wang,Yuchen Zhang,Fan Yang,Tianyu Zeng,Fanchen Meng,Mengzhu Yang,Yiqi Yang,Yijia Hua,Ziyi Fu,Jun Li,Xiang Huang,Hao Wu,Yongmei Yin,Wei Li
出处
期刊:Frontiers in Oncology [Frontiers Media SA]
卷期号:11: 628677- 被引量:1
标识
DOI:10.3389/fonc.2021.628677
摘要

Cancer-associated fibroblasts (CAFs) are key components in tumor microenvironment (TME). The secreted products of CAFs play important roles in regulating tumor cells and further impacting clinical prognosis. This study aims to reveal the relationship between CAF-secreted cytokines and breast cancer (BC) by constructing the risk signature. We performed three algorithms to reveal CAF-related cytokines in the TCGA BC dataset and identified five prognosis-related cytokines. Then we used single-cell RNA sequencing (ScRNA-Seq) datasets of BC to confirm the expression level of these five cytokines in CAFs. METABRIC and other independent datasets were utilized to validate the findings in further analyses. Based on the identified five-cytokine signature derived from CAFs, BC patients with high-risk score (RS) had shorter overall survival than low-RS cases. Further analysis suggested that the high-RS level correlated with cell proliferation and mast cell infiltration in BCs of the Basal-like subtype. The results also indicated that the level of RS could discriminate the high-risk BC cases harboring driver mutations (i.e., PI3KCA, CDH1, and TP53). Additionally, the status of five-cytokine signature was associated with the frequency and molecular timing of whole genome duplication (WGD) events. Intratumor heterogeneity (ITH) analysis among BC samples indicated that the high-RS level was associated with the increase of tumor subclones. This work demonstrated that the prognostic signature based on CAF-secreted cytokines was associated with clinical outcome, tumor progression, and genetic alteration. Our findings may provide insights to develop novel strategies for early intervention and prognostic prediction of BC.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
1秒前
Ava应助神勇葵阴采纳,获得10
2秒前
Kepler关注了科研通微信公众号
3秒前
虾米YYY完成签到,获得积分10
3秒前
chruse发布了新的文献求助10
3秒前
4秒前
ddaa发布了新的文献求助10
4秒前
5秒前
小封发布了新的文献求助10
6秒前
小屋完成签到,获得积分10
6秒前
虞丹萱完成签到,获得积分10
9秒前
pysa发布了新的文献求助20
10秒前
seedcode发布了新的文献求助10
10秒前
10秒前
脑洞疼应助小封采纳,获得10
11秒前
hy发布了新的文献求助10
14秒前
Ava应助Samaritan采纳,获得10
16秒前
喜喜完成签到 ,获得积分20
16秒前
美女完成签到 ,获得积分10
16秒前
桐桐应助科研通管家采纳,获得10
17秒前
17秒前
17秒前
17秒前
深情安青应助科研通管家采纳,获得10
18秒前
科研通AI2S应助科研通管家采纳,获得10
18秒前
天天快乐应助科研通管家采纳,获得10
18秒前
赘婿应助科研通管家采纳,获得10
18秒前
18秒前
18秒前
xinanan发布了新的文献求助10
18秒前
缥缈冰珍完成签到 ,获得积分10
19秒前
AILOLIHH完成签到,获得积分10
19秒前
斯文败类应助chruse采纳,获得10
20秒前
ddaa完成签到,获得积分10
22秒前
22秒前
23秒前
hy完成签到,获得积分20
23秒前
gb发布了新的文献求助10
24秒前
华仔应助小凉采纳,获得10
24秒前
高分求助中
Evolution 3rd edition 1500
保险藏宝图 1000
Lire en communiste 1000
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 700
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 700
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3184432
求助须知:如何正确求助?哪些是违规求助? 2834802
关于积分的说明 8001217
捐赠科研通 2497134
什么是DOI,文献DOI怎么找? 1332684
科研通“疑难数据库(出版商)”最低求助积分说明 636650
邀请新用户注册赠送积分活动 603979