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Associations between blood and urinary manganese with metabolic syndrome and its components: Cross-sectional analysis of National Health and Nutrition Examination Survey 2011–2016

腰围 全国健康与营养检查调查 医学 优势比 代谢综合征 置信区间 内科学 横断面研究 泌尿系统 血脂异常 内分泌学 生理学 环境卫生 体质指数 肥胖 人口 病理
作者
Kenneth Lo,Jing Yang,Chaolei Chen,Lin Liu,Yuqing Huang,Yingqing Feng,Ai-Min Yang
出处
期刊:Science of The Total Environment [Elsevier BV]
卷期号:780: 146527-146527 被引量:28
标识
DOI:10.1016/j.scitotenv.2021.146527
摘要

Manganese (Mn) may improve cardiometabolic health with its anti-oxidative ability. However, epidemiological evidence on the overall and sex-specific relationship between Mn exposure and metabolic syndrome (MetS) has been inconclusive. We evaluated the associations of urinary (n = 1713) and blood (n = 3335) Mn levels with the prevalence of MetS, its components (elevated waist circumference, impaired glucose metabolism, elevated blood pressure and dyslipidemia) and sex-dependent heterogeneities among participants in the United States National Health and Nutrition Examination Survey 2011–2016. After adjusting for multiple covariates and the levels of other metals (Arsenic, Barium, Cadmium, Mercury, Molybdenum, Tin and Uranium), urinary Mn at the third quartile associated with a lower odd of MetS (odds ratio [OR] = 0.55, 95% confidence interval [C.I.] = 0.32–0.97), elevated waist circumference (OR = 0.56, 95% C.I. = 0.36–0.86) and elevated fasting plasma glucose (OR = 0.46, 95% C.I. = 0.27–0.76) among overall participants, and lower odds of MetS (OR = 0.40, 95% C.I. = 0.16–0.99), elevated waist circumference (OR = 0.39, 95% C.I. = 0.19–0.81) and elevated fasting plasma glucose (OR = 0.44, 95% C.I. = 0.22–0.90) among men. The U-shaped dose-response relationship between urinary Mn and MetS (P non-linear = 0.008) was observed among all participants. We did not observe the significant associations of blood Mn with the prevalence of MetS. Compared with other metals, urinary Mn played a less important role in development of MetS (posterior inclusion probabilities [PIP] = 0.49 for Mn versus 0.54 to 0.91 for other metals), but the contribution of blood Mn (PIP = 0.59 versus 0.60 to 0.61) was similar to other blood metals (Cadmium, Lead, Mercury and Selenium). These findings have provided new evidence of the potential roles of Mn in cardiometabolic health, and the needs to explore how Mn interacts with multiple metals in sex-specific manner.
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