Sleep and Porphyromonas Gingivalis K-Capsular IgG Serotypes: A Study in the Old Order Amish

Sleep problems and inflammatory periodontal disease have a bidirectional relationship and are independently linked with depression, dementia, and metabolic illness. A key player in periodontal disease is Porphyromonas gingivalis, a bacteria that can translocate to the brain and induce miRNA’s. Antibodies to P. gingivalis capsular virulence factors, K1-7, have been used to estimate P. gingivalis virulence. We hypothesized that sleep impairment is positively associated with P. gingivalis K IgG serointensity.