细菌
噬菌体
微生物学
噬菌体疗法
生物
抗生素耐药性
致病菌
肠沙门氏菌
沙门氏菌
抗菌剂
抗生素
人类病原体
病毒学
病菌
细菌病毒
大肠杆菌
遗传学
基因
作者
Evan N. Bennett,Shallee T. Page
标识
DOI:10.1096/fasebj.2022.36.s1.0r807
摘要
Antibiotic resistance is a critical problem in medicine, whereby pathogenic bacteria become able to overcome medicinal treatments One approach to fighting antibiotic resistance is the use of bacteriophages ("phages"), viruses that attack bacteria, a strategy known as "phage therapy". Phages can target specific bacteria, thereby avoiding the problem of antibiotics that kill a wide spectrum of bacteria, including neutral or beneficial bacteria. Phages have been used as antibiotics for a century, but suffer from two limitations: a) bacteria acquire phage resistance; and b) phage effects in the test tube were observed to differ from their effects in the body. Thus, we have isolated a bacteriophage against a human pathogen Salmonella enterica serovar typhimurium and have fully characterized its growth and annotated its genome. Then, we tested its ability to mitigate Salmonella infection in C. elegans.
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