生物
发病机制
疾病
聚ADP核糖聚合酶
程序性细胞死亡
细胞生物学
转录因子
肌萎缩侧索硬化
细胞凋亡
遗传学
免疫学
医学
聚合酶
病理
DNA
基因
作者
Libo Liu,Jiaxiang Li,Yueshuang Ke,Xianlu Zeng,Jinmin Gao,Xueqing Ba,Ruoxi Wang
标识
DOI:10.1007/s00018-021-04109-w
摘要
Parthanatos is a form of regulated cell death involved in the pathogenesis of many diseases, particularly neurodegenerative disorders, such as Parkinson's disease, Alzheimer's disease, Huntington’s disease, and amyotrophic lateral sclerosis. Parthanatos is a multistep cell death pathway cascade that involves poly (ADP-ribose) polymerase 1 (PARP-1) overactivation, PAR accumulation, PAR binding to apoptosis-inducing factor (AIF), AIF release from the mitochondria, nuclear translocation of the AIF/macrophage migration inhibitory factor (MIF) complex, and MIF-mediated large-scale DNA fragmentation. All the key players in the parthanatos pathway are pleiotropic proteins with diverse functions. An in-depth understanding of the structure-based activity of the key factors, and the biochemical mechanisms of parthanatos, is crucial for the development of drugs and therapeutic strategies. In this review, we delve into the key players of the parthanatos pathway and reveal the multiple levels of therapeutic opportunities for treating parthanatos-based pathogenesis.
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