TGF beta 2 fuels inflammation and fibrosis in cholestatic liver disease through macrophage and myofibroblast recruitment and activation

Figure: Intrabiliary 5-OP-RU injection in iValpha19 Tg Calpha -/-mice activates MAIT cells. Conclusion:We observed a clear activation of hepatic MAIT cells in a mouse model of bile duct inflammation that led to cholangitis.Biliary antigens potentially derived from gut microbiota present in the bile ducts could therefore be speculated to induce an immune response where MAIT cells play a role.