Metabolic Profiling of Bladder Cancer Patients’ Serum Reveals Their Sensitivity to Neoadjuvant Chemotherapy

牛磺酸 谷氨酰胺 代谢组学 次黄嘌呤 化疗 膀胱癌 顺铂 内科学 多元分析 氨基酸 氟尿苷 医学 药理学 生物 肿瘤科 癌症 生物化学 生物信息学 氟尿嘧啶
作者
Juntao Zhuang,Xiao Yang,Qi Zheng,Kai Li,Lingkai Cai,Hao Yu,Jiancheng Lv,Kexin Bai,Qiang Cao,Pengchao Li,Haiwei Yang,Junsong Wang,Qiang Lü
出处
期刊:Metabolites [MDPI AG]
卷期号:12 (6): 558-558 被引量:13
标识
DOI:10.3390/metabo12060558
摘要

Numerous patients with muscle-invasive bladder cancer develop low responsiveness to cisplatin. Our purpose was to explore differential metabolites derived from serum in bladder cancer patients treated with neoadjuvant chemotherapy (NAC). Data of patients diagnosed with cT2-4aNxM0 was collected. Blood samples were retained prospectively before the first chemotherapy for untargeted metabolomics by 1H-NMR and UPLC-MS. To identify characterized metabolites, multivariate statistical analyses were applied, and the intersection of the differential metabolites discovered by the two approaches was used to identify viable biomarkers. A total of 18 patients (6 NAC-sensitive patients and 12 NAC-resistant patients) were enrolled. There were 29 metabolites detected by 1H-NMR and 147 metabolites identified by UPLC-MS. Multivariate statistics demonstrated that in the sensitive group, glutamine and taurine were considerably increased compared to their levels in the resistant group, while glutamate and hypoxanthine were remarkably decreased. Pathway analysis and enrichment analysis showed significant alterations in amino acid pathways, suggesting that response to chemotherapy may be related to amino acid metabolism. In addition, hallmark analysis showed that DNA repair played a regulatory role. Overall, serum metabolic profiles of NAC sensitivity are significantly different in bladder cancer patients. Glycine, hypoxanthine, taurine and glutamine may be the potential biomarkers for clinical treatment. Amino acid metabolism has potential value in enhancing drug efficacy.
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