化学
2,4-二硝基苯酚
光化学
组合化学
生物化学
作者
Uma Devi Newar,Satheesh Borra,Ram Awatar Maurya
出处
期刊:Organic Letters
[American Chemical Society]
日期:2022-06-14
卷期号:24 (24): 4454-4458
被引量:14
标识
DOI:10.1021/acs.orglett.2c01691
摘要
A novel and efficient visible-light 2,4-dinitrophenol (2,4-DNP) mediated photoannulation of α-azidochalcones into 2,5-diaryloxazoles was developed. The carbon-carbon double bond of α-azidochalcone was cleaved, leading to the formation of new C-O and C-N bonds in the photoannulation. Control experiments were carried out, and a plausible mechanism of the photoannulation was proposed. The scope of the reaction was studied by synthesizing a series of 2,5-diaryloxazoles including two naturally occurring oxazoles (Texamine and Balsoxin) in excellent yields.
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