离子交换树脂
安贝莱特
药品
分子
化学
机制(生物学)
分子间力
组合化学
有机化学
药理学
吸附
医学
认识论
哲学
作者
Conghui Li,Xiaolu Han,Xiaoxuan Hong,Xianfu Li,Hui Zhang,Zengming Wang,Aiping Zheng
出处
期刊:Polymers
[MDPI AG]
日期:2021-12-15
卷期号:13 (24): 4394-4394
被引量:14
标识
DOI:10.3390/polym13244394
摘要
Since the advent of ion exchange resin, it has been widely used in many fields, including drug delivery systems. The drug binds to the resin through an exchange reaction to form a drug-resin complex, which can gradually release drugs through the exchange of physiological ions in the gastrointestinal tract, to realize functions such as taste masking and regulating release. In this study, the complexes of methylphenidate hydrochloride and Amberlite IRP69 were prepared and evaluated to explore the mechanism of complexation, influencing factors and release mechanism at a molecular level. Firstly, with the properties of the selected complexes, molecular dynamics simulation was innovatively used to find that the intermolecular interaction between drug molecules and ion exchange resin molecules is mainly caused by the stacking effect of π and salt bridges. Secondly, with the drug loading status as an indicator, the factors affecting the compounding process of the drug and resin were explored. Finally, the release mechanism of the drug-resin complex was studied by mathematical model fitting. In summary, a variety of methods were used to study the mechanism of complexation and release between drug and resin, providing a theoretical basis for promoting the marketing of ion-exchange resin-mediated oral preparations.
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