癌症研究
三阴性乳腺癌
T细胞
免疫学
免疫系统
医学
生物
乳腺癌
癌症
内科学
作者
Pei Kee Goh,Florian Wiede,Mara N. Zeissig,Kara L. Britt,Shuwei Liang,Tim Molloy,Nathan Gödde,Rachel Xu,Sherene Loi,Mathias Müller,Patrick O. Humbert,Catriona McLean,Tony Tiganis
出处
期刊:Science Advances
[American Association for the Advancement of Science (AAAS)]
日期:2022-02-23
卷期号:8 (8)
被引量:28
标识
DOI:10.1126/sciadv.abk3338
摘要
The tumor-suppressor PTPN2 is diminished in a subset of triple-negative breast cancers (TNBCs). Paradoxically, PTPN2-deficiency in tumors or T cells in mice can facilitate T cell recruitment and/or activation to promote antitumor immunity. Here, we explored the therapeutic potential of targeting PTPN2 in tumor cells and T cells. PTPN2-deficiency in TNBC associated with T cell infiltrates and PD-L1 expression, whereas low PTPN2 associated with improved survival. PTPN2 deletion in murine mammary epithelial cells TNBC models, did not promote tumorigenicity but increased STAT-1–dependent T cell recruitment and PD-L1 expression to repress tumor growth and enhance the efficacy of anti-PD-1. Furthermore, the combined deletion of PTPN2 in tumors and T cells facilitated T cell recruitment and activation and further repressed tumor growth or ablated tumors already predominated by exhausted T cells. Thus, PTPN2-targeting in tumors and/or T cells facilitates T cell recruitment and/or alleviates inhibitory constraints on T cells to combat TNBC.
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