Non-targeted analysis of unknown volatile components in scented stationery via headspace GC-Orbitrap MS

This paper reports the non-targeted analysis of unknown volatile components in scented stationery based on headspace gas chromatography-Orbitrap high-resolution mass spectrometry. The volatiles released from the samples (22 scented erasers and 17 scented pens) under specific headspace conditions were analyzed. A qualitative analysis of unknown substances was carried out according to four identification steps (step 1: comprehensive score and retention index, step 2: identification of molecular ion peaks by chemical ionization, step 3: fragment ion detail comparison for distinguishing isomers, step 4: verification by chemical standards). A total of 101 volatile substances were identified in the scented erasers, and 86 volatile substances were identified in the scented pens. The identified substances were divided into eight categories. Aliphatic hydrocarbons, aromatic hydrocarbons, esters, and alcohols were the top four groups of substances identified in scented erasers and pens. The identified substances were further filtered and screened according to their detection rate, toxicity, and response intensity. Finally, 14 high-risk volatile chemicals in scented stationery were listed. This study can be used as a reference for identifying unknown substances and as a guide for monitoring volatile chemicals in products and assessing their possible risks to consumers.