突触素
胆碱乙酰转移酶
维甲酸
神经突
神经颗粒素
谷氨酸脱羧酶
细胞生物学
生物
SH-SY5Y型
酪氨酸羟化酶
化学
内分泌学
多巴胺
生物化学
信号转导
胆碱能的
神经母细胞瘤
细胞培养
酶
体外
免疫学
免疫组织化学
蛋白激酶C
基因
遗传学
作者
Sneha Singh,Rishi K. Somvanshi,Ujendra Kumar
出处
期刊:Biomedicines
[MDPI AG]
日期:2022-02-01
卷期号:10 (2): 337-337
被引量:4
标识
DOI:10.3390/biomedicines10020337
摘要
During brain development, neurite formation plays a critical role in neuronal communication and cognitive function. In the present study, we compared developmental changes in the expression of crucial markers that govern the functional activity of neurons, including somatostatin (SST), choline acetyltransferase (ChAT), tyrosine hydroxylase (TH), brain nitric oxide synthase (bNOS), gamma-aminobutyric acid (GABA), glutamic acid decarboxylase (GAD-65) and synaptic vesicle protein synaptophysin (SYP) in non-differentiated and retinoic acid (RA)-induced differentiated SH-SY5Y cells. We further determined the role of SST in regulating subcellular distribution and expression of neurotransmitters. Our results indicate that SST potentiates RA-induced differentiation of SH-SY5Y cells and involves regulating the subcellular distribution and expression of neurotransmitter markers and synaptophysin translocation to neurites in a time-dependent manner, anticipating the therapeutic implication of SST in neurodegeneration.
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