仿生学
仿生材料
合成生物学
超分子化学
功能(生物学)
自组装
生物矿化
纳米技术
计算机科学
材料科学
化学
计算生物学
生物
进化生物学
晶体结构
古生物学
结晶学
作者
Aviad Levin,Tuuli A. Hakala,Lee Schnaider,Gonçalo J. L. Bernardes,Ehud Gazit,Tuomas P. J. Knowles
标识
DOI:10.1038/s41570-020-0215-y
摘要
Natural biomolecular systems have evolved to form a rich variety of supramolecular materials and machinery fundamental to cellular function. The assembly of these structures commonly involves interactions between specific molecular building blocks, a strategy that can also be replicated in an artificial setting to prepare functional materials. The self-assembly of synthetic biomimetic peptides thus allows the exploration of chemical and sequence space beyond that used routinely by biology. In this Review, we discuss recent conceptual and experimental advances in self-assembling artificial peptidic materials. In particular, we explore how naturally occurring structures and phenomena have inspired the development of functional biomimetic materials that we can harness for potential interactions with biological systems. As our fundamental understanding of peptide self-assembly evolves, increasingly sophisticated materials and applications emerge and lead to the development of a new set of building blocks and assembly principles relevant to materials science, molecular biology, nanotechnology and precision medicine. The self-assembly of biomimetic peptides can mimic complex natural systems involving whole proteins. This Review describes how synthetic peptides afford tunable scaffolds for biomineralization, drug delivery and tissue growth.
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