Infertile women with endometriosis possess differences in cytokine levels in various tissues

子宫内膜异位症 不育 医学 子宫内膜 细胞因子 腹膜液 男科 内科学 妇科 内分泌学 生物 怀孕 遗传学
作者
Lingge Jin,Xiangyan Ruan,Jing Jin,Yu Wang,Yudi Zhang,Qi Zhou,Dan Lu,Alfred Otto Mueck
出处
期刊:Gynecological Endocrinology [Informa]
卷期号:: 1-5
标识
DOI:10.1080/09513590.2022.2060961
摘要

(1) To characterize the cytokine expression profiles of endometriosis related infertile women in comparison to fertile women with endometriosis; (2) to investigate the correlation of the cytokine levels from different tissues.100 stage IV endometriosis patients were recruited and grouped by infertility status (n = 50, separately). Concentrations of TNF-α, TGF-β1, IL-10, and IL-17A from the serum, peritoneal fluid (PF), eutopic, and ectopic endometrium samples were measured.(1) In the infertile group, the concentrations of IL-10 within serum, PF and eutopic endometrium were all significantly higher (p = .022 and <.01, .013, respectively), the levels of TGF-β1 in serum and eutopic endometrium samples were both higher (p = .025 and p < .01), the levels of IL-17A in the PF, eutopic, and ectopic endometrium were all lower (p < .01, all). (2) Significant positive correlation was observed between IL-17A from PF and the ectopic endometrium (p = .014), IL-17A from PF and eutopic endometrium (p < .01). The PF IL-10 levels positively correlated with those in the serum (p = .007).This is the first study comparing the levels of cytokines within four different tissues of endometriosis women with or without infertility. The study revealed that endometriosis-related infertile women possess significant differences in cytokine levels in comparison to fertile women with endometriosis. The levels of inflammatory factors from different tissues had certain positive correlations. Infertility may indicate the progress of the disease.
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