Data‐mining‐based of ancient traditional Chinese medicine records from 475 BC to 1949 to potentially treat COVID‐19

Traditional Chinese Medicine (TCM) plays a role in preventing and treating COVID-19 in China. Based on the manifestations and symptoms of COVID-19, our study used the data mining method to summarize related therapeutic experience left by predecessors who used TCM to treat epidemics in their eras. Initially, we collected abundant medical records with similar manifestations of COVID-19 in Chinese ancient times. The key words including wen (), yi (), li (), and zhang () were searched in ZhongyiZhiku (https://www.zk120.com/) from Warring States Period (475 BC-221 BC) to the Republic of China era (1912-1949) to locate ancient medical records according to inclusion criteria and exclusion criteria. Moreover, COVID-19-related manifestations and corresponding medications in those records were categorized. Eventually, Traditional Chinese Medicine Inheritance Support System version 2.5 was used to build a medical record database of TCM treating COVID-19. Our study collected 263 epidemic medical records comprising COVID-19 related manifestations and found that Chinese Materia Medica (CMM) combinations excavated from ancient medical records included Ren Shen Bai Du San, Wu Ling San, Xiao Chai Hu Tang, Da Cheng Qi Tang, Da Chai Hu Tang, Ling Gui Zhu Gan Tang, and Qing Wen Bai Du Yin. The recurrent CMMs with a high frequency for treating COVID-19 manifestations were Scutellariae Radix (Huang Qin), Paeoniae Alba Radix (Bai Shao), Poria (Fu Ling), and Bupleuri Radix (Chai Hu). Our study suggests that TCM might offer new therapeutic strategies for COVID-19.中医药在预防和治疗新型冠状病毒肺炎中发挥重要作用。为了应对该病并探索中医药治疗的方法，本项研究基于其临床表现，采用数据挖掘的方法，总结前人留下的宝贵的治疗经验。首先收集大量古代与该病症状相似的医案，根据纳入标准和排除标准，在中医智库(https://www.zk120.com/)中查找从战国(公元前475-公元前221年)至中华民国(1912-1949)时期包含关键词瘟、疫、疠、瘴的医案。随后，用EXCEL分类医案中与该病相关的症状及其所使用的方药。最后，利用中医传承发展平台(TCMISS) 2.5版创建了中医治疗的医案数据库。研究结果共收集263份包含该病相关症状的医案，并根据挖掘出的药物组合锁定人参败毒散、五苓散、小柴胡汤、大承气汤、大柴胡汤、苓桂术甘汤及清瘟败毒饮，同时发现治疗该病的高频次药物包括黄芩、白芍、茯苓及柴胡。研究表明，中医药为新型冠状病毒肺炎的治疗提供了有价值的策略。.