Recent Advances in Nucleophilic Fluorination Reactions of Organic Compounds­ Using Deoxofluor and DAST

Selective fluorination of organic compounds continues to be a stimulating and exciting area of research. While a variety of fluorinating reagents and methodologies have been developed to fulfill the increasing demand for site selective fluorination of organic compounds, applications of Deoxofluor and DAST continue to be used widely. Our interest in applying synthetic methods for introducing fluorine or a fluorinated group into a large variety of organic compounds encouraged this review which highlights recent progress in fluorination reactions using Deoxofluor [bis(2-methoxyethyl)aminosulfur trifluoride] and DAST (diethylaminosulfur trifluoride) as key nucleophilic fluorinating reagents. This review covers the literature for fluorination reactions of organic compounds using Deoxofluor and DAST from January 1999 through July 2002.