Direct association between high fat dietary pattern and risk of being in the higher stages of chronic kidney disease

Background: Although there are some reports on the association of dietary patterns and chronic kidney disease (CKD), no data exists regarding the relation between dietary pattern and CKD from developing countries. Objective: To examine the association between major dietary patterns, renal function and progression of CKD. Methods: Two hundred twenty one subjects with diagnosed CKD were selected for this cross-sectional study. Dietary intake of patients was assessed by a validated food frequency questionnaire. Major dietary patterns were extracted by factor analysis. Renal function was measured by blood urea nitrogen (BUN) and serum creatinine (Cr) level as well as estimated glomerular filtration rate (eGFR). Results: Three major dietary patterns were identified: high fruits and vegetables, high simple carbohydrate and sugar and high fat. Subjects in the second quartile of high fat dietary pattern score had lower Cr and higher eGFR in compared with the first quartile after adjusting for covariates (P = 0.02 for both). After adjusting for confounders (age, physical activity, socioeconomic status, height, weight, systolic and diastolic blood pressure and energy intake), patients in the top quartile of high fat dietary pattern score were found to be at greater risk of being in the higher stages (stage 3 vs. stages 4 and 5) of CKD (odds ratio: 3.09; 95% CI: 1.23, 7.76; P for trend = 0.02). Conclusion: We observed that a high fat dietary pattern was directly associated with progression of CKD.