Sensitive electrochemical platform based on nano-cylindrical strontium titanate/N-doped graphene hybrid composite for simultaneous detection of diphenhydramine and bromhexine

Abstract Herein, we report a nano-cylindrical strontium titanate/N-doped graphene (SrTiO 3 /N-GNS) hybrid composite synthesized by a solvothermal method. The composite material has been explored by various physicochemical and electrochemical characterization techniques. It is found that the nano-cylindrical SrTiO 3 nanoparticles with highly crystalline mesoporous structure are consistently present in between as well as on the surface of N-GNS sheets resulted in 3-dimensional continuous structure. The electrochemical investigations reveal that SrTiO 3 /N-GNS hybrid composite displays excellent electrocatalytic behavior towards simultaneous electro-oxidation of two commonly encountered anti-allergic drugs viz. Diphenhydramine (DPH) and Bromhexine (BRO) in phosphate buffer of pH 7.0 employing adsorptive stripping differential pulse voltammetry. The new application of SrTiO 3 /N-GNS hybrid as an electrochemical sensor shows wide linear working range from 0.038 to 100.0 μM for DPH and 0.030–90.0 μM for BRO with detection limit of 2.1 and 1.9 nM respectively. Also, the developed sensor manifests adequate recoveries in synthetic pharmaceutical samples and human body fluids. These findings suggest that SrTiO 3 /N-GNS composite is and could serve as a potential candidate for highly sensitive electrochemical sensing applications.