胸腺基质淋巴细胞生成素
先天性淋巴细胞
生物
白细胞介素33
受体
间质细胞
细胞生物学
转录组
内生
白细胞介素
免疫学
细胞因子
基因表达
癌症研究
先天免疫系统
基因
内分泌学
遗传学
作者
Roberto R. Ricardo-González,Steven J. Van Dyken,Christoph Schneider,Jinwoo Lee,Jesse C. Nussbaum,Hong‐Erh Liang,Dedeepya Vaka,Walter L. Eckalbar,Ari B. Molofsky,David J. Erle,Richard M. Locksley
出处
期刊:Nature Immunology
[Springer Nature]
日期:2018-09-10
卷期号:19 (10): 1093-1099
被引量:338
标识
DOI:10.1038/s41590-018-0201-4
摘要
Group 2 innate lymphoid cells (ILC2s) are distributed systemically and produce type 2 cytokines in response to a variety of stimuli, including the epithelial cytokines interleukin (IL)-25, IL-33, and thymic stromal lymphopoietin (TSLP). Transcriptional profiling of ILC2s from different tissues, however, grouped ILC2s according to their tissue of origin, even in the setting of combined IL-25-, IL-33-receptor-, and TSLP-receptor-deficiency. Single-cell profiling confirmed a tissue-organizing transcriptome and identified ILC2 subsets expressing distinct activating receptors, including the major subset of skin ILC2s, which were activated preferentially by IL-18. Tissue ILC2 subsets were unaltered in number and expression in germ-free mice, suggesting that endogenous, tissue-derived signals drive the maturation of ILC2 subsets by controlling expression of distinct patterns of activating receptors, thus anticipating tissue-specific perturbations occurring later in life.
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