Recent Trends in Hydroxyapatite (HA) Synthesis and the Synthesis Report of Nanostructure HA by Hydrothermal Reaction

This research summary the trend in synthesis of Hydroxyapatite (HA) using different route such as dry method and wet method (co-precipitation method; emulsion method, hydrolysis method, sol-gel method, hydrothermal method). In addition, the research group also report the technique to synthesis nano-structure HA by hydrothermal reaction using Ca(OH)2 and H3PO4 with the Ca/P molar ratio of 1.67. The mixture after homogenized for 2 h, follow by hydrothermal reaction at different hydrothermal temperature time (100 °C, 150 °C, and 180 °C) and different hydrothermal reaction time (0 h, 12 h and 24 h). The 180 °C-hydrothermal treated-HA has needle-like shape with the diameter of 10 ~ 20 nm and length of below 100 nm, which is similar with human bone. For the hydrothermal reaction, temperature is the key to form nanostructure HA.