调节器
辅活化剂
生物
效应器
转录调控
过氧化物酶体增殖物激活受体
背景(考古学)
细胞生物学
转录因子
抄写(语言学)
计算生物学
过氧化物酶体
核受体
受体
遗传学
基因
语言学
哲学
古生物学
作者
Karl N. Miller,Josef P. Clark,Rozalyn M. Anderson
标识
DOI:10.1016/j.coemr.2019.02.002
摘要
Peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1a) is a central regulator of metabolism that is poised at the intersection of myriad intracellular signaling pathways. In this brief update, we discuss regulation of PGC-1a at multiple levels, including transcriptional, post-transcriptional, and post-translational modifications. We discuss recently identified small molecule effectors of PGC-1a that offer translational potential and promise new insight into PGC-1a biology. We highlight novel mechanistic insights relating to PGC-1a's interactions with RNA to enhance transcription and potentially influence transcript processing. Finally, we place these exciting new data in the context of aging biology, offering PGC-1a as a candidate target with terrific potential in anti-aging interventions.
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