Attenuated effect of zinc gluconate on oxidative stress, inflammation, and angiogenic imbalance in pre-eclampsia rats

氧化应激 炎症 内科学 内分泌学 医学 怀孕 妊娠期 生物 遗传学
作者
Qi Lang,Jinyan Wei,Mengran Tian,Shudan Wei,Xiangyuan Yu,Chaochao Zhao,Jun Zhang,Bo Huang
出处
期刊:Life Sciences [Elsevier BV]
卷期号:310: 121055-121055 被引量:7
标识
DOI:10.1016/j.lfs.2022.121055
摘要

Pre-eclampsia (PE) is a common obstetric disease associated with oxidative stress, systemic inflammation, and angiogenic imbalance, whereas zinc (Zn) presents anti-oxidative and anti-inflammatory effects. This study is to investigate whether zinc gluconate (ZG) supplementation may ameliorate the early signs, adverse pregnancy outcomes, and pathogenic processes of PE in an animal model.Forty pregnant Wistar rats were randomly divided into four groups: blank control (treated with normal saline, NS), Zn control (treated with ZG and followed by NS), PE model (treated with NS and followed by nitro-L-arginine methyl ester, L-NAME), and PE intervention (treated with ZG and followed by L-NAME). ZG (5 mg/kg/day) or NS was administered by gavage from day 0 to 19 of gestation, and L-NAME (80 mg/kg/day) or NS was subcutaneously injected from day 4 to 19 of gestation. The blood pressure, urinary protein, and pregnancy outcomes were recorded. Oxidative stress, inflammation, and angiogenic homeostasis were evaluated.PE rats exhibited oxidative stress (reduced SOD, CAT, and GSH, and increased MDA and 3-NT), inflammation (increased IL-6 and TNF-α), and angiogenic imbalance (reduced VEGF and PlGF, and increased sFlt-1). After intervention with ZG, the blood pressure and urinary protein levels were reverted, and the pregnancy outcomes were improved. The oxidative stress, inflammation, and angiogenic imbalance were effectively restored in accompany by increased Zn and MT levels.ZG can ameliorate the early signs and pathological processes of PE in the animal model, indicating the value of zinc supplementation during pregnancy for PE prevention.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
小张发布了新的文献求助10
1秒前
1秒前
LY发布了新的文献求助10
2秒前
个性的冬卉完成签到,获得积分10
2秒前
传奇3应助Gaara0504采纳,获得10
3秒前
NexusExplorer应助科研通管家采纳,获得10
3秒前
传奇3应助科研通管家采纳,获得10
3秒前
reirei应助科研通管家采纳,获得10
3秒前
Hello应助科研通管家采纳,获得10
3秒前
Lucas应助科研通管家采纳,获得50
3秒前
3秒前
英姑应助科研通管家采纳,获得10
4秒前
Hello应助科研通管家采纳,获得10
4秒前
Owen应助科研通管家采纳,获得10
4秒前
情怀应助科研通管家采纳,获得10
4秒前
丘比特应助科研通管家采纳,获得10
4秒前
我是老大应助科研通管家采纳,获得10
4秒前
上官若男应助科研通管家采纳,获得10
4秒前
4秒前
丘比特应助科研通管家采纳,获得10
4秒前
4秒前
4秒前
GXX应助科研通管家采纳,获得10
4秒前
Newt应助科研通管家采纳,获得20
4秒前
Mea完成签到,获得积分10
6秒前
yuaasusanaann发布了新的文献求助10
7秒前
nura发布了新的文献求助10
7秒前
小6s发布了新的文献求助10
7秒前
沉静冬灵应助吉小聿采纳,获得20
7秒前
9秒前
9秒前
9秒前
玺鱼完成签到,获得积分10
11秒前
12秒前
淡淡天蓝完成签到,获得积分10
12秒前
陈美净完成签到,获得积分10
12秒前
科研通AI5应助义气萝卜头采纳,获得10
12秒前
12秒前
13秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3976210
求助须知:如何正确求助?哪些是违规求助? 3520366
关于积分的说明 11203088
捐赠科研通 3256965
什么是DOI,文献DOI怎么找? 1798570
邀请新用户注册赠送积分活动 877738
科研通“疑难数据库(出版商)”最低求助积分说明 806516