益生菌
活性氧
溃疡性结肠炎
医学
药理学
化学
微生物学
免疫学
生物
生物化学
内科学
细菌
遗传学
疾病
作者
Jun Liu,Yixin Wang,William J. Heelan,Yu Chen,Zhaoting Li,Quanyin Hu
出处
期刊:Science Advances
[American Association for the Advancement of Science (AAAS)]
日期:2022-11-11
卷期号:8 (45)
被引量:79
标识
DOI:10.1126/sciadv.abp8798
摘要
Inflammatory bowel diseases (IBDs) are often associated with elevated levels of reactive oxygen species (ROS) and highly dysregulated gut microbiota. In this study, we synthesized a polymer of hyaluronic acid–poly(propylene sulfide) (HA-PPS) and developed ROS-scavenging nanoparticles (HPN) that could effectively scavenge ROS. To achieve colon tissue targeting effects, the HPN nanoparticles were conjugated to the surface of modified probiotic Escherichia coli Nissle 1917 (EcN). To enhance the bacteriotherapy of EcN, we encapsulated EcN cells with a poly-norepinephrine (NE) layer that can protect EcN against environmental assaults to improve the viability of EcN in oral delivery and prolong the retention time of EcN in the intestine due to its strong mucoadhesive capability. In the dextran sulfate sodium–induced mouse colitis models, HPN-NE-EcN showed substantially enhanced prophylactic and therapeutic efficacy. Furthermore, the abundance and diversity of gut microbiota were increased after treatment with HPN-NE-EcN, contributing to the alleviation of IBDs.
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